Evidence map›Paper›PMID 39528717›Full record

ArticleNPJ precision oncology2024

LSD1 deficiency in breast cancer cells promotes the formation of pre-metastatic niches.

Yutong Yao, Rui Qian, Hanwei Gao, Yonghao Dai, Yueru Shi, Peipei An, Benkai Xin, Ziyu Liu, Nan Zhang, Youzhong Wan and 2 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in NPJ precision oncology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Review
  2. Review
  3. Review
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Yutong YaoCancer Biology Laboratory, China-Japan Union Hospital of Jilin University, Jilin University, Changchun, Jilin, China.
Rui QianCancer Biology Laboratory, China-Japan Union Hospital of Jilin University, Jilin University, Changchun, Jilin, China.
Hanwei GaoCancer Biology Laboratory, China-Japan Union Hospital of Jilin University, Jilin University, Changchun, Jilin, China.
Yonghao DaiCancer Biology Laboratory, China-Japan Union Hospital of Jilin University, Jilin University, Changchun, Jilin, China.
Yueru ShiCancer Biology Laboratory, China-Japan Union Hospital of Jilin University, Jilin University, Changchun, Jilin, China.
Peipei AnCancer Biology Laboratory, China-Japan Union Hospital of Jilin University, Jilin University, Changchun, Jilin, China.
Benkai XinCancer Biology Laboratory, China-Japan Union Hospital of Jilin University, Jilin University, Changchun, Jilin, China.
Ziyu LiuCancer Biology Laboratory, China-Japan Union Hospital of Jilin University, Jilin University, Changchun, Jilin, China.
Nan ZhangDepartment of Cardiology, China-Japan Union Hospital of Jilin University, Jilin University, Changchun, Jilin, China.
Youzhong WanCancer Biology Laboratory, China-Japan Union Hospital of Jilin University, Jilin University, Changchun, Jilin, China.
Yuquan HeDepartment of Cardiology, China-Japan Union Hospital of Jilin University, Jilin University, Changchun, Jilin, China.
Xin HuDepartment of Cardiology, China-Japan Union Hospital of Jilin University, Jilin University, Changchun, Jilin, China. huxin@jlu.edu.cn.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Lysine-specific demethylase 1 (LSD1), a histone demethylating enzyme, plays a crucial role in cancer metastasis. Studies show LSD1 knockout promotes breast cancer lung metastasis, but it's unknown if it alters the lung microenvironment for metastasis. In this study, we investigated the effects of exosomes from LSD1-knockdown (LSD1 KD) breast cancer cells on pre-metastatic niche formation. Injecting exosomes from LSD1 KD cells in mice resulted in a substantial increase in lung colonization by breast cancer cells, while treatment with exosomes derived from LSD1 KD cells decreased the expression of the ZO-1 and occludin, leading to increased vascular permeability. The LSD1 KD reduced the expression of circDOCK1, which augmented the levels of miR-1270 in exosomes. And miR-1270 inhibited ZO-1 expression in human endothelial cells, which enhanced their permeability. Our study uncovered a novel mechanism in which the LSD1 promotes the formation of pre-metastatic niches via the regulation of exosomal miRNA.

Identifiers

PMID39528717
PMCPMC11555121

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.