Evidence map›Paper›PMID 39528663›Full record

ArticleSurgical endoscopy2025

Short-term efficacy and safety of endoscopic injection of low dose of sclerotherapy and cyanoacrylate injection for type GOV1 gastric varices combined with endoscopic variceal ligation for esophageal varices.

Tingting Zhang, Chuangyang Xin, Xueyun Guo, Sihai Chen, Xuelian Zheng, Wen Xu, Dongjing Zhang, Biming Li, Ye Chen, Xuan Zhu and 1 more

Abstract read
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In one paragraph

Article in Surgical endoscopy, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Tingting ZhangDepartment of Gastroenterology and Hepatology, The First Affiliated Hospital of Nanchang University, No. 17, Yongwaizheng Street, Nanchang, China.
Chuangyang XinDepartment of Gastroenterology and Hepatology, The First Affiliated Hospital of Nanchang University, No. 17, Yongwaizheng Street, Nanchang, China.
Xueyun GuoDepartment of Gastroenterology and Hepatology, The First Affiliated Hospital of Nanchang University, No. 17, Yongwaizheng Street, Nanchang, China.
Sihai ChenDepartment of Gastroenterology and Hepatology, The First Affiliated Hospital of Nanchang University, No. 17, Yongwaizheng Street, Nanchang, China.
Xuelian ZhengDepartment of Gastroenterology and Hepatology, The First Affiliated Hospital of Nanchang University, No. 17, Yongwaizheng Street, Nanchang, China.
Wen XuDepartment of Gastroenterology and Hepatology, Shenzhen Clinical Research Center for Digestive Disease, Shenzhen Hospital, Southern Medical University, No.1333, Xinhu Road, Shenzhen, China.
Dongjing ZhangDepartment of Gastroenterology and Hepatology, Shenzhen Clinical Research Center for Digestive Disease, Shenzhen Hospital, Southern Medical University, No.1333, Xinhu Road, Shenzhen, China.
Biming LiDepartment of Gastroenterology and Hepatology, The First Affiliated Hospital of Nanchang University, No. 17, Yongwaizheng Street, Nanchang, China.
Ye ChenDepartment of Gastroenterology and Hepatology, Shenzhen Clinical Research Center for Digestive Disease, Shenzhen Hospital, Southern Medical University, No.1333, Xinhu Road, Shenzhen, China.
Xuan ZhuDepartment of Gastroenterology and Hepatology, The First Affiliated Hospital of Nanchang University, No. 17, Yongwaizheng Street, Nanchang, China.
Anjiang WangDepartment of Gastroenterology and Hepatology, The First Affiliated Hospital of Nanchang University, No. 17, Yongwaizheng Street, Nanchang, China. waj1103@163.com.ORCID 0000-0001-6670-6645

Funding

Key Research and Development Project of Department of Science and Technology of Jiangxi Province 20202BBGL73093National Natural Science Foundation of China 82160115Project of Department of Education of Jiangxi Province GJJ200164Science and Technology Planning Project of Health and Family Planning Commission of Jiangxi Province 202210459
6 · The paper itself

Abstract

backgroundTo explore the short-term efficacy and safety of endoscopic low dose injection of sclerotherapy and cyanoacrylate for gastric varices (GVs) combined with endoscopic variceal ligation (EVL) for esophageal varices (EVs) in cirrhosis with type GOV1 varices.

methodsA total of 521 patients with cirrhosis and GOV1 varices, who were divided into emergence endoscopy treatment layer and secondary prophylaxis for rebleeding layer, were selected. All patients underwent combined therapy or EVL alone (ligation therapy) for the treatment of type GOV1 varices. The baseline between the two groups with significant differences were used as covariates for 1:1 propensity score matching. The early rebleeding rate was compared and the risk factors for rebleeding were identified in each layer.

resultsAfter propensity score matching, a total of 122 patients were included in the emergence endoscopy treatment layer, and 234 patients were included in the secondary prophylaxis layer. The early rebleeding rates in the combined therapy group vs. ligation therapy group was 4.92% vs. 16.39% (P = 0.04) and 2.56% vs. 1.71% (P = 0.65) in the emergency endoscopy layer and in the secondary prophylaxis layer, respectively. The median length of hospital stay after endoscopy was 8 days vs. 9 days (P = 0.004) and 7 days vs. 6 days (P = 0.47), in each layer respectively. There was no significant difference in the adverse reactions of endoscopic treatment. EVL treatment (OR: 3.84; 95% CI: 1.05-13.96; P = 0.04) and discontinuation of NSBB (non-selective beta-blocker) use after discharge (OR: 3.58; 95% CI: 1.20-10.67; P = 0.02) were independent risk factors for early rebleeding after endoscopy in the emergency endoscopy layer.

conclusionCombined therapy is comparable with ligation therapy in the short-term efficacy and safety of in cirrhosis patients with secondary prophylaxis for rebleeding while it is superior to EVL alone in cirrhosis in the emergency endoscopy treatment as it could reduce the early rebleeding rate and shorten the length of hospital stay.

Indexed as

CyanoacrylatesEsophageal and Gastric VaricesGastrointestinal HemorrhageSclerotherapyAdultAgedCombined Modality TherapyFemaleHumansLigationLiver CirrhosisMaleMiddle AgedRecurrenceRetrospective StudiesSclerosing SolutionsCyanoacrylatesSclerosing SolutionsEndoscopic injection of sclerotherapyEndoscopic variceal ligationEndoscopic variceal obliterationEsophagogastric variceal bleedingGastroesophageal variceal type 1

Identifiers

PMID39528663

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.