Evidence map›Paper›PMID 39528615›Full record

ArticleScientific reports2024

Multicellular adaptation to electrophysiological perturbations analyzed by deterministic and stochastic bioelectrical models.

Javier Cervera, Michael Levin, Salvador Mafe

Abstract read
In one paragraph

Article in Scientific reports, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Javier CerveraDept. Termodinàmica, Facultat de Física, Universitat de València, Burjassot, 46100, Spain. javier.cervera@uv.es.
Michael LevinAllen Discovery Center, Tufts University, Medford, MA, 02155-4243, USA.
Salvador MafeDept. Termodinàmica, Facultat de Física, Universitat de València, Burjassot, 46100, Spain.

Funding

Guy Foundation Family Trust 103733-00001Ministerio de Ciencia e Innovación PID2022-139953NB-I00TWCF TWCF0606
6 · The paper itself

Abstract

Cells can compensate a disruptive change in one ion channel by compensatory changes in other channels. We have simulated the adaptation of a multicellular aggregate of non-excitable cells to the electrophysiological perturbation produced by the external blocking of a cation channel. In the biophysical model employed, we consider that this blocking provokes a cell depolarization that opens a voltage-gated calcium channel, thus allowing toxic Ca

Indexed as

Adaptation, PhysiologicalMembrane PotentialsModels, BiologicalAlgorithmsAnimalsCalciumCalcium ChannelsComputer SimulationElectrophysiological PhenomenaIon ChannelsPlanariansStochastic ProcessesCalciumCalcium ChannelsIon Channels

Identifiers

PMID39528615
PMCPMC11554804

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.