Evidence map›Paper›PMID 39528583›Full record

ArticleScientific reports2024

Protective effects of Marinobacter nauticus strain GH3 exopolysaccharide on the Oreochromis niloticus model for Alzheimer's disease.

Ghada Abdel-Razik, Mohamad Abdelrazik, Alaa Rashad, Wagdy K B Khalil, Fagr Kh Abdel-Gawad, Ahmed A Hamed, Mohamed E El Awady

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Review
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Ghada Abdel-RazikBotany and Microbiology Department, Faculty of Science, Suez Canal University, Ismailia, 41522, Egypt.
Mohamad AbdelrazikBotany and Microbiology Department, Faculty of Science, Suez Canal University, Ismailia, 41522, Egypt.
Alaa RashadBotany and Microbiology Department, Faculty of Science, Suez Canal University, Ismailia, 41522, Egypt.
Wagdy K B KhalilCenter of Excellence for Research and Applied Studies on Climate Change and Sustainable Development, National Research Centre (NRC), 33 El Bohouth St. Dokki, Giza, 12622, Egypt.
Fagr Kh Abdel-GawadCenter of Excellence for Research and Applied Studies on Climate Change and Sustainable Development, National Research Centre (NRC), 33 El Bohouth St. Dokki, Giza, 12622, Egypt.
Ahmed A HamedMicrobial Chemistry Department, National Research Centre, El-Buhouth St. 33, Dokki-Cairo, Giza, 12622, Egypt.
Mohamed E El AwadyMicrobial Biotechnology Department, National Research Centre, El-Buhouth St. 33, Dokki- Cairo 12622, Giza, Egypt. Mohamed_elawady82@yahoo.com.ORCID http://orcid.org/0000-0001-5155-3949

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Marinobacter nauticus strain GH3 was isolated from the Red Sea, Sharm Elshiekh, and classified according to cultural attributes, biochemical properties, and the analysis of genetic relationships using 16 S rRNA sequences. A substantial proportion of exopolysaccharides (EPS) in GH3-EPS contained a sulfate content of 25.4%, uronic acid (12.18%), and N-acetylglucosamine (13.6%). The composition of monosaccharides in this fraction consists of glucose, glucoronic acid, arabinose, and xylose by 2:4:3:3, respectively. SEM showed a flower-like shape with white bundles on the GH3-EPS surface. GH3-EPS enhancement of the RAW264.7 macrophage line RAW 264.7 ATTC number J774 cell proliferation via MTT assay for cell viability. GH3-EPS had a high stimulation effect on releasing TNF-alpha and IL-10. Followed by its effect against cyclooxygenase (COX-2) and lipoxygenase (LOX), with IC

Indexed as

Alzheimer DiseaseDisease Models, AnimalPolysaccharides, BacterialAnimalsAntioxidantsCell SurvivalMiceRAW 264.7 CellsAntioxidantsPolysaccharides, BacterialAlzheimer’s diseaseAntioxidantExopolysaccharideImmunomodulatoryNeurodegenerative disordersOreochromis niloticus

Identifiers

PMID39528583
PMCPMC11555282

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.