Evidence map›Paper›PMID 39528575›Full record

ArticleScientific reports2024

Local and systemic humoral immune responses to Histophilus somni recombinant antigens administered intranasally and subcutaneously to dairy calves.

Joanna Bazjert, Paulina Jawor, Maciej Pisarek, Rafał Baran, Wojciech Jachymek, Tadeusz Stefaniak

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Joanna BazjertDepartment of Immunology, Pathophysiology and Veterinary Preventive Medicine, Wrocław University of Environmental and Life Sciences, C.K. Norwida 31 Str, Wrocław, 50-375, Poland. joanna.bajzert@upwr.edu.pl.
Paulina JaworDepartment of Immunology, Pathophysiology and Veterinary Preventive Medicine, Wrocław University of Environmental and Life Sciences, C.K. Norwida 31 Str, Wrocław, 50-375, Poland.
Maciej PisarekDepartment of Immunology, Pathophysiology and Veterinary Preventive Medicine, Wrocław University of Environmental and Life Sciences, C.K. Norwida 31 Str, Wrocław, 50-375, Poland.
Rafał BaranDepartment of Immunology, Pathophysiology and Veterinary Preventive Medicine, Wrocław University of Environmental and Life Sciences, C.K. Norwida 31 Str, Wrocław, 50-375, Poland.
Wojciech JachymekHirszfeld Institute of Immunology and Experimental Therapy, Polish Academy of Science, Rudolfa Weigla 12 Str, Wrocław, 53-114, Poland.
Tadeusz StefaniakDepartment of Immunology, Pathophysiology and Veterinary Preventive Medicine, Wrocław University of Environmental and Life Sciences, C.K. Norwida 31 Str, Wrocław, 50-375, Poland.

Funding

Wrocław University of Environmental and Life Sciences N060/0019/20
6 · The paper itself

Abstract

Bovine respiratory disease (BRD) causes significant economic losses in dairy calves. Induction of an early immune response via parenteral vaccination is complicated by the interference of colostral immunity. In this study, we investigated early immunization against selected conserved bacterial antigens. Calves were vaccinated twice intranasally and then subcutaneously with Histophilus somni recombinant proteins (rOMP40 or rHsp60) mixed with one of two adjuvants: CpG ODN2007 or MPLA. The control group (Con) was treated with PBS. The first immunization was done between 24 and 48 h of life and then twice in two weeks intervals. Blood, nasal, and saliva secretion samples were collected directly before vaccination (S1-S3) and then on 42-44 (S4) and 59-61 (S5) day of life. Antibodies (IgG

Indexed as

Administration, IntranasalAntibodies, BacterialAntigens, BacterialImmunity, HumoralPasteurellaceaeAdjuvants, ImmunologicAnimalsBacterial VaccinesCattleCattle DiseasesImmunoglobulin GInjections, SubcutaneousPasteurellaceae InfectionsRecombinant ProteinsVaccinationAdjuvants, ImmunologicAntibodies, BacterialAntigens, BacterialBacterial VaccinesImmunoglobulin GRecombinant ProteinsCpG ODN2007MPLArHsp60 H. somnirOMP40 H. somni

Identifiers

PMID39528575
PMCPMC11555116

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.