Evidence map›Paper›PMID 39528548›Full record

ArticleNPJ vaccines2024

Irradiated whole cell Chlamydia vaccine confers significant protection in a murine genital tract challenge model.

Kieran C Broder, Vera Y Matrosova, Rok Tkavc, Elena K Gaidamakova, Lam Thuy Vi Tran Ho, Andrew N Macintyre, Anthony Soc, Aissata Diallo, Stephen C Darnell, Sarah Bash and 3 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in NPJ vaccines, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Profile ofHuman vaccines & immunotherapeutics · 2025
    Article
  5. mBio · 2025
    Article
  6. The ternary complex of MnProceedings of the National Academy of Sciences of the United States of America · 2024
    Article
  7. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Kieran C BroderDepartment of Microbiology and Immunology, Uniformed Services University of the Health Sciences, Bethesda, MD, USA.
Vera Y MatrosovaHenry M. Jackson Foundation for the Advancement of Military Medicine, Bethesda, MD, USA.
Rok TkavcDepartment of Microbiology and Immunology, Uniformed Services University of the Health Sciences, Bethesda, MD, USA.
Elena K GaidamakovaHenry M. Jackson Foundation for the Advancement of Military Medicine, Bethesda, MD, USA.ORCID http://orcid.org/0000-0002-1121-3699
Lam Thuy Vi Tran HoDepartment of Microbiology and Immunology, Uniformed Services University of the Health Sciences, Bethesda, MD, USA.
Andrew N MacintyreDepartment of Medicine, Duke Human Vaccine Institute, Durham, NC, USA.
Anthony SocDepartment of Microbiology and Immunology, Uniformed Services University of the Health Sciences, Bethesda, MD, USA.
Aissata DialloDepartment of Microbiology and Immunology, Uniformed Services University of the Health Sciences, Bethesda, MD, USA.
Stephen C DarnellDepartment of Microbiology and Immunology, Uniformed Services University of the Health Sciences, Bethesda, MD, USA.
Sarah BashDepartment of Microbiology and Immunology, Uniformed Services University of the Health Sciences, Bethesda, MD, USA.
Michael J DalyDepartment of Pathology, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. michael.daly@usuhs.edu.
Ann E JerseDepartment of Microbiology and Immunology, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. ann.jerse1@usuhs.edu.ORCID http://orcid.org/0000-0002-5118-3172
George W LiechtiDepartment of Microbiology and Immunology, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. george.liechti@usuhs.edu.ORCID http://orcid.org/0000-0003-3028-8474

Funding

Cellular organization, division, and differentiation in an ancient, genetically reduced bacteriumR35GM138202 · NIGMS · HENRY M. JACKSON FDN FOR THE ADV MIL/MED · PI GEORGE WARREN LIECHTI · 2020 to 2026
$2.0M
United States Department of Defense | Uniformed Services University of the Health Sciences (Uniformed Services University) HP73LIEC18United States Department of Defense | Uniformed Services University of the Health Sciences (Uniformed Services University) MIC-73-12926United States Department of Defense | Uniformed Services University of the Health Sciences (Uniformed Services University) MIC-73-9925U.S. Department of Health & Human Services | NIH | National Institute of General Medical Sciences (NIGMS) GM138202
6 · The paper itself

Abstract

Chlamydia trachomatis infections are the most common bacterial STIs globally and can lead to serious morbidity if untreated. Development of a killed, whole-cell vaccine has been stymied by coincident epitope destruction during inactivation. Here, we present a prototype Chlamydia vaccine composed of elementary bodies (EBs) from the related mouse pathogen, Chlamydia muridarum (Cm). EBs inactivated by gamma rays (Ir-Cm) in the presence of the antioxidant Mn

Identifiers

PMID39528548
PMCPMC11554809

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.