Evidence map›Paper›PMID 39528503›Full record

ArticleScientific reports2024

A prevalent caveolin-1 gene rs926198 variant is associated with type 2 diabetes mellitus in the Thai population.

Metha Yaikwawong, Pornpimon Ek-Eudomsuk, Gunya Sittithumcharee, Vipavee Anupunpisit, Thavatchai Peerapatdit, Chaicharn Deerochanawong, Thep Himathongkam, Siwanon Jirawatnotai, Somlak Chuengsamarn

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Article in Scientific reports, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Not yet cited in PubMed.

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0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

9 authors.

Metha YaikwawongDepartment of Pharmacology, Faculty of Medicine, Siriraj Hospital, Mahidol University, Bangkok, 10700, Thailand.
Pornpimon Ek-EudomsukSiriraj Center of Research for Excellence, Siriraj Center of Research for Excellence for Systems Pharmacology, Faculty of Medicine, Siriraj Hospital, Mahidol University, Bangkok, 10700, Thailand.
Gunya SittithumchareeSiriraj Center of Research for Excellence, Siriraj Center of Research for Excellence for Systems Pharmacology, Faculty of Medicine, Siriraj Hospital, Mahidol University, Bangkok, 10700, Thailand.
Vipavee AnupunpisitDepartment of Anatomy, Faculty of Medicine, Srinakharinwirot University, Bangkok, 10110, Thailand.
Thavatchai PeerapatditDivision of Endocrinology and Metabolism, Faculty of Medicine, Siriraj Hospital, Mahidol University, Bangkok, 10700, Thailand.
Chaicharn DeerochanawongDivision of Endocrinology and Metabolism, Department of Medicine, Rajavithi Hospital, Bangkok, 10400, Thailand.
Thep HimathongkamTheptarin Diabetes Center and Hospital, Bangkok, 10110, Thailand.
Siwanon JirawatnotaiDepartment of Pharmacology, Faculty of Medicine, Siriraj Hospital, Mahidol University, Bangkok, 10700, Thailand. siwanon.jir@mahidol.ac.th.
Somlak ChuengsamarnDivision of Endocrinology and Metabolism, Faculty of Medicine, HRH Princess Maha Chakri Sirindhorn Medical Center, Srinakharinwirot University, Nakhon Nayok, 26120, Thailand. somlukc@hotmail.com.

Funding

National Research of Council Thailand 010/2557Siriraj Foundation D003421
6 · The paper itself

Abstract

This study investigated the associations between CAV1 variants and metabolic syndrome (MetS), type 2 diabetes mellitus (T2DM), and cardiometabolic risk factors, as well as the influence of CAV1 variants on CAV1 mRNA expression. We genotyped 743 T2DM patients for CAV1 variants. Multiple logistic regression was conducted to adjust for sex, age, and body mass index (BMI), and odds ratios (ORs) with 95% confidence intervals (CIs) were calculated. The expression of mRNA was measured by reverse transcription polymerase chain reaction. The rs926198 variant, but not the rs3807989 variant, was associated with T2DM. Crude ORs were 1.87 (95% CI: 1.32-2.69, p = 0.0005) and adjusted ORs were 1.81 (95% CI: 1.12-2.96, p = 0.016), respectively. Additionally, patients with Mets and T2DM who had the rs926198 variant exhibited a significant 44.3% reduction in CAV1 mRNA expression (P < 0.05). Clinical samples revealed that the rs926198 variant is strongly linked to T2DM, with significantly reduced CAV1 mRNA. Our findings suggest a crucial role for the rs926198 variant in T2DM, indicating its potential for prevention, diagnosis, and intervention purposes.

Indexed as

Caveolin 1Diabetes Mellitus, Type 2Polymorphism, Single NucleotideAdultAgedFemaleGenetic Predisposition to DiseaseGenotypeHumansMaleMetabolic SyndromeMiddle AgedRNA, MessengerSoutheast Asian PeopleThailandCAV1 protein, humanCaveolin 1RNA, MessengerCardiometabolic risk factorsCAV1 geneInsulin resistanceMetabolic syndromers926198 variantType 2 diabetes mellitus

Identifiers

PMID39528503
PMCPMC11555279

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.