Evidence map›Paper›PMID 39528494›Full record

ArticleNature communications2024

Epidemiological data of an influenza A/H5N1 outbreak in elephant seals in Argentina indicates mammal-to-mammal transmission.

Marcela M Uhart, Ralph E T Vanstreels, Martha I Nelson, Valeria Olivera, Julieta Campagna, Victoria Zavattieri, Philippe Lemey, Claudio Campagna, Valeria Falabella, Agustina Rimondi

Abstract read
In one paragraph

Article in Nature communications, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 83 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
83citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

83 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Counting cases, conserving species: addressing highly pathogenic avian influenza in wildlife.Biological reviews of the Cambridge Philosophical Society · 2026
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23 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Marcela M UhartKaren C. Drayer Wildlife Health Center, School of Veterinary Medicine, University of California, Davis, USA. muhart@ucdavis.edu.ORCID 0000-0003-3525-541X
Ralph E T VanstreelsKaren C. Drayer Wildlife Health Center, School of Veterinary Medicine, University of California, Davis, USA.
Martha I NelsonNational Center for Biotechnology Information, National Library of Medicine, National Institutes of Health, Bethesda, USA.
Valeria OliveraInstituto de Virología e Innovaciones Tecnológicas, INTA-CONICET, Buenos Aires, Argentina.ORCID 0009-0004-1950-2366
Julieta CampagnaWildlife Conservation Society, Argentina Program, Buenos Aires, Argentina.ORCID 0000-0001-8142-5235
Victoria ZavattieriWildlife Conservation Society, Argentina Program, Buenos Aires, Argentina.
Philippe LemeyDepartment of Microbiology, Immunology and Transplantation, Rega Institute, Laboratory for Clinical and Epidemiological Virology, KU Leuven, Leuven, Belgium.ORCID 0000-0003-2826-5353
Claudio CampagnaWildlife Conservation Society, Argentina Program, Buenos Aires, Argentina.ORCID 0000-0002-7971-5062
Valeria FalabellaWildlife Conservation Society, Argentina Program, Buenos Aires, Argentina.ORCID 0000-0003-2737-6916
Agustina RimondiInstituto de Virología e Innovaciones Tecnológicas, INTA-CONICET, Buenos Aires, Argentina. rimondia@rki.de.ORCID 0000-0002-2021-1134

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

H5N1 high pathogenicity avian influenza virus has killed thousands of marine mammals in South America since 2022. Here we report epidemiological data and full genome characterization of clade 2.3.4.4b H5N1 HPAI viruses associated with a massive outbreak in southern elephant seals (Mirounga leonina) at Península Valdés, Argentina, in October 2023. We also report on H5N1 viruses in concurrently dead terns. Our genomic analysis shows that viruses from pinnipeds and terns in Argentina form a distinct clade with marine mammal viruses from Peru, Chile, Brazil and Uruguay. Additionally, these marine mammal clade viruses share an identical set of mammalian adaptation mutations which were also present in tern viruses. Our combined ecological and phylogenetic data support mammal-to-mammal transmission and occasional mammal-to-bird spillover and suggest multinational transmission of H5N1 viruses in mammals. We reflect that H5N1 viruses becoming more evolutionary flexible and adapting to mammals in new ways could have global consequences for wildlife, humans, and/or livestock.

Indexed as

Disease OutbreaksInfluenza A Virus, H5N1 SubtypeOrthomyxoviridae InfectionsPhylogenySeals, EarlessAnimalsArgentinaGenome, Viral

Identifiers

PMID39528494
PMCPMC11555070

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.