Evidence map›Paper›PMID 39528469›Full record

ArticleNature communications2024

Evasion of antiviral bacterial immunity by phage tRNAs.

Aa Haeruman Azam, Kohei Kondo, Kotaro Chihara, Tomohiro Nakamura, Shinjiro Ojima, Wenhan Nie, Azumi Tamura, Wakana Yamashita, Yo Sugawara, Motoyuki Sugai and 4 more

Abstract read
In one paragraph

Article in Nature communications, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers.

0numbers the graph read from it
0cells of the map it votes in
36citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

36 citing papers in PubMed.

  1. Article
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  7. Review
  8. Article
  9. Article
  10. Article
  11. Article
  12. Article
  13. Article
  14. Structure and mechanism of antiphage retron Eco2.Nature structural & molecular biology · 2026
    Article
  15. Article
  16. Giant linear plasmids in Mycobacterium avium harbour a tRNA array unit.DNA research : an international journal for rapid publication of reports on genes and genomes · 2026
    Article
  17. Article
  18. Genomic analysis ofVirus evolution · 2026
    Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Aa Haeruman AzamResearch Center for Drug and Vaccine Development, National Institute of Infectious Diseases, Shinjuku, Tokyo, Japan.
Kohei KondoAntimicrobial Resistance Research Center, National Institute of Infectious Diseases, Higashi Murayama, Tokyo, Japan.
Kotaro ChiharaResearch Center for Drug and Vaccine Development, National Institute of Infectious Diseases, Shinjuku, Tokyo, Japan.ORCID 0000-0002-2694-2560
Tomohiro NakamuraResearch Center for Drug and Vaccine Development, National Institute of Infectious Diseases, Shinjuku, Tokyo, Japan.
Shinjiro OjimaResearch Center for Drug and Vaccine Development, National Institute of Infectious Diseases, Shinjuku, Tokyo, Japan.
Wenhan NieResearch Center for Drug and Vaccine Development, National Institute of Infectious Diseases, Shinjuku, Tokyo, Japan.
Azumi TamuraResearch Center for Drug and Vaccine Development, National Institute of Infectious Diseases, Shinjuku, Tokyo, Japan.
Wakana YamashitaResearch Center for Drug and Vaccine Development, National Institute of Infectious Diseases, Shinjuku, Tokyo, Japan.
Yo SugawaraAntimicrobial Resistance Research Center, National Institute of Infectious Diseases, Higashi Murayama, Tokyo, Japan.ORCID 0000-0002-9897-3905
Motoyuki SugaiAntimicrobial Resistance Research Center, National Institute of Infectious Diseases, Higashi Murayama, Tokyo, Japan.ORCID 0000-0001-9252-7739
Longzhu CuiDivision of Bacteriology, Department of Infection and Immunity, School of Medicine, Jichi Medical University, Shimotsuke-shi, Tochigi, Japan.ORCID 0000-0002-8909-3885
Yoshimasa TakahashiResearch Center for Drug and Vaccine Development, National Institute of Infectious Diseases, Shinjuku, Tokyo, Japan.ORCID 0000-0001-6342-4087
Koichi WatashiResearch Center for Drug and Vaccine Development, National Institute of Infectious Diseases, Shinjuku, Tokyo, Japan.ORCID 0000-0002-4536-9966
Kotaro KigaResearch Center for Drug and Vaccine Development, National Institute of Infectious Diseases, Shinjuku, Tokyo, Japan. k-kiga@niid.go.jp.ORCID 0000-0002-0248-6951

Funding

Japan Agency for Medical Research and Development (AMED) JP21fk0108496Japan Agency for Medical Research and Development (AMED) JP21gm1610002Japan Agency for Medical Research and Development (AMED) JP21wm0325022Japan Agency for Medical Research and Development (AMED) JP22fk0108532Japan Agency for Medical Research and Development (AMED) JP22fk0108562Japan Agency for Medical Research and Development (AMED) JP23fk0108599Japan Agency for Medical Research and Development (AMED) JP23wm0325065Japan Agency for Medical Research and Development (AMED) JP24fk0108698MEXT | Japan Society for the Promotion of Science (JSPS) 21H02110MEXT | Japan Society for the Promotion of Science (JSPS) 21K19666MEXT | Japan Society for the Promotion of Science (JSPS) 22K20575MEXT | Japan Society for the Promotion of Science (JSPS) 23K13876MEXT | Japan Society for the Promotion of Science (JSPS) 23K19475
6 · The paper itself

Abstract

Retrons are bacterial genetic elements that encode a reverse transcriptase and, in combination with toxic effector proteins, can serve as antiphage defense systems. However, the mechanisms of action of most retron effectors, and how phages evade retrons, are not well understood. Here, we show that some phages can evade retrons and other defense systems by producing specific tRNAs. We find that expression of retron-Eco7 effector proteins (PtuA and PtuB) leads to degradation of tRNA

Indexed as

BacteriophagesRNA, TransferAnticodonBacteriaEscherichia coliViral ProteinsAnticodonRNA, TransferViral Proteins

Identifiers

PMID39528469
PMCPMC11555353

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.