Evidence map›Paper›PMID 39528407›Full record

ArticleEuropean journal of clinical investigation2025

Hemodynamic responses at anaerobic threshold during exercise in preload insufficiency.

Shoaib Fakhri, Luiz Campedelli, Michael G Risbano

Abstract read
In one paragraph

Article in European journal of clinical investigation, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
  2. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Shoaib FakhriDivision of Pulmonary, Allergy, and Critical Care Medicine, Department of Medicine, University of Pittsburgh School of Medicine and UPMC, Pittsburgh, Pennsylvania, USA.
Luiz CampedelliDepartment of Internal Medicine, Boston University Medical Center, Boston, Massachusetts, USA.ORCID https://orcid.org/0009-0007-4311-7654
Michael G RisbanoDivision of Pulmonary, Allergy, and Critical Care Medicine, Department of Medicine, University of Pittsburgh School of Medicine and UPMC, Pittsburgh, Pennsylvania, USA.ORCID https://orcid.org/0000-0003-3334-7046

Funding

Shadyside Hospital Foundation
6 · The paper itself

Abstract

backgroundPreload insufficiency is an underrecognized cause of exercise intolerance identified during invasive cardiopulmonary exercise testing, and defined hemodynamically by decreased biatrial filling pressures, cardiac output, and oxygen consumption (V̇O

methodsWe compared submaximal cardiopulmonary hemodynamics, measured at anaerobic threshold, between preload insufficiency patients and age-matched controls referred for dyspnea but with normal exercise responses.

resultsOur study included 66 patients: 41 with preload insufficiency and 25 controls. Preload insufficiency patients exhibit significantly reduced V̇O

conclusionsThese findings underscore the profound impact of preload insufficiency on submaximal exercise capacity, emphasizing the importance of its recognition and management. This insight sets the stage for further investigations into interventions targeting preload insufficiency at submaximal exercise levels to enhance both exercise performance and quality of life.

Indexed as

Anaerobic ThresholdDyspneaExerciseExercise ToleranceHemodynamicsAdultAgedCardiac OutputCase-Control StudiesExercise TestFemaleHeart RateHumansMaleMiddle AgedOxygen Consumptionanaerobic thresholddyspnea on exertioninvasive cardiopulmonary exercise testingpreload insufficiencysubmaximal exercise

Identifiers

PMID39528407
PMCPMC11744911

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.