Evidence map›Paper›PMID 39528403›Full record

ArticleChemistry (Weinheim an der Bergstrasse, Germany)2025

Organocatalytic Electrophilic Arene Amination: Rapid Synthesis of 2-Quinolones.

Tamal Kanti Das, Arghya Ghosh, Zachary Grimm, Ulises Aguinaga, Muhammed Yousufuddin, László Kürti

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Chemistry (Weinheim an der Bergstrasse, Germany), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Tamal Kanti DasDepartment of Chemistry, Rice University, Houston, Texas, 77030, USA.ORCID https://orcid.org/0000-0003-0517-4184
Arghya GhoshDepartment of Chemistry, Rice University, Houston, Texas, 77030, USA.ORCID https://orcid.org/0009-0001-9414-7470
Zachary GrimmDepartment of Chemistry, Rice University, Houston, Texas, 77030, USA.
Ulises AguinagaDepartment of Natural Sciences, University of North Texas at Dallas, Dallas, Texas, 75241, USA.
Muhammed YousufuddinDepartment of Natural Sciences, University of North Texas at Dallas, Dallas, Texas, 75241, USA.
László KürtiDepartment of Chemistry, Rice University, Houston, Texas, 77030, USA.ORCID https://orcid.org/0000-0002-3412-5894

Funding

New catalytic methods for the rapid synthesis of N-unprotected chiral aziridines and aminesR35GM136373 · NIGMS · RICE UNIVERSITY · PI KURTI, LASZLO · 2020 to 2024
$2.1M
Division of Chemistry CHE-2102462NIGMS NIH HHS R35 GM-136373NIGMS NIH HHS R35 GM136373Welch Foundation C-1764
6 · The paper itself

Abstract

For decades, the synthesis of 2-quinolones, a crucial structural motif in pharmaceuticals and agrochemicals, has relied heavily on costly noble metal complexes and structurally complex ligands. Despite considerable efforts from synthetic chemists, a mild, metal-free, environmentally friendly, and cost-effective approach has remained elusive. This study introduces a robust, metal-free synthetic platform that leverages an innovative organoiodine-catalyzed electrophilic arene C(sp

Indexed as

2-QuinolonesElectrophilic arene aminationOrganocatalyticOrganoiodine

Identifiers

PMID39528403
PMCPMC11890162

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.