Evidence map›Paper›PMID 39528299›Full record

ArticleAJNR. American journal of neuroradiology2025

Ultra-High-Resolution Photon-Counting-Detector CT with a Dedicated Denoising Convolutional Neural Network for Enhanced Temporal Bone Imaging.

Shaojie Chang, John C Benson, John I Lane, Michael R Bruesewitz, Joseph R Swicklik, Jamison E Thorne, Emily K Koons, Matthew L Carlson, Cynthia H McCollough, Shuai Leng

Abstract read
In one paragraph

Article in AJNR. American journal of neuroradiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Photon-counting detector computed tomography for temporal bone: does higher resolution matter?Current opinion in otolaryngology & head and neck surgery · 2026
    Review
  2. Article
  3. Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Shaojie ChangFrom the Depsartment of Radiology (S.C., J.C.B., J.I.L., M.R.B., J.R.S., J.E.T., E.K.K., M.L.C., C.H.M., S.L.), Mayo Clinic, Rochester, Minnesota.
John C BensonFrom the Depsartment of Radiology (S.C., J.C.B., J.I.L., M.R.B., J.R.S., J.E.T., E.K.K., M.L.C., C.H.M., S.L.), Mayo Clinic, Rochester, Minnesota.ORCID 0000-0002-4038-5422
John I LaneFrom the Depsartment of Radiology (S.C., J.C.B., J.I.L., M.R.B., J.R.S., J.E.T., E.K.K., M.L.C., C.H.M., S.L.), Mayo Clinic, Rochester, Minnesota.ORCID 0000-0001-5874-633X
Michael R BruesewitzFrom the Depsartment of Radiology (S.C., J.C.B., J.I.L., M.R.B., J.R.S., J.E.T., E.K.K., M.L.C., C.H.M., S.L.), Mayo Clinic, Rochester, Minnesota.ORCID 0000-0002-7291-7913
Joseph R SwicklikFrom the Depsartment of Radiology (S.C., J.C.B., J.I.L., M.R.B., J.R.S., J.E.T., E.K.K., M.L.C., C.H.M., S.L.), Mayo Clinic, Rochester, Minnesota.
Jamison E ThorneFrom the Depsartment of Radiology (S.C., J.C.B., J.I.L., M.R.B., J.R.S., J.E.T., E.K.K., M.L.C., C.H.M., S.L.), Mayo Clinic, Rochester, Minnesota.ORCID 0000-0003-3993-6423
Emily K KoonsFrom the Depsartment of Radiology (S.C., J.C.B., J.I.L., M.R.B., J.R.S., J.E.T., E.K.K., M.L.C., C.H.M., S.L.), Mayo Clinic, Rochester, Minnesota.
Matthew L CarlsonFrom the Depsartment of Radiology (S.C., J.C.B., J.I.L., M.R.B., J.R.S., J.E.T., E.K.K., M.L.C., C.H.M., S.L.), Mayo Clinic, Rochester, Minnesota.ORCID 0000-0002-4925-8593
Cynthia H McColloughFrom the Depsartment of Radiology (S.C., J.C.B., J.I.L., M.R.B., J.R.S., J.E.T., E.K.K., M.L.C., C.H.M., S.L.), Mayo Clinic, Rochester, Minnesota.ORCID 0000-0002-5346-332X
Shuai LengFrom the Depsartment of Radiology (S.C., J.C.B., J.I.L., M.R.B., J.R.S., J.E.T., E.K.K., M.L.C., C.H.M., S.L.), Mayo Clinic, Rochester, Minnesota Leng.Shuai@mayo.edu.ORCID 0000-0002-6453-9481

Funding

Comprehensive characterization of coronary atherosclerotic disease using photon-counting-detector dual-source CT and its impact on patient managementR01EB028590 · NIBIB · MAYO CLINIC ROCHESTER · PI LENG, SHUAI, MCCOLLOUGH, CYNTHIA H · 2020 to 2023
$2.6M
NIBIB NIH HHS R01 EB028590
6 · The paper itself

Abstract

background and purposeUltra-high-resolution (UHR) photon-counting-detector (PCD) CT improves image resolution but increases noise, necessitating the use of smoother reconstruction kernels that reduce resolution below the 0.125-mm maximum spatial resolution. A denoising convolutional neural network (CNN) was developed to reduce noise in images reconstructed with the available sharpest reconstruction kernel while preserving resolution for enhanced temporal bone visualization to address this issue. MATERIALS AND

methodsWith institutional review board approval, the CNN was trained on 6 patient cases of clinical temporal bone imaging (1885 images) and tested on 20 independent cases using a dual-source PCD-CT (NAEOTOM Alpha). Images were reconstructed using quantum iterative reconstruction at strength 3 (QIR3) with both a clinical routine kernel (Hr84) and the sharpest available head kernel (Hr96). The CNN was applied to images reconstructed with Hr96 and QIR1 kernel. For each case, three series of images (Hr84-QIR3, Hr96-QIR3, and Hr96-CNN) were randomized for review by 2 neuroradiologists assessing the overall quality and delineating the modiolus, stapes footplate, and incudomallear joint.

resultsThe CNN reduced noise by 80% compared with Hr96-QIR3 and by 50% relative to Hr84-QIR3, while maintaining high resolution. Compared with the conventional method at the same kernel (Hr96-QIR3), Hr96-CNN significantly decreased image noise (from 204.63 to 47.35 HU) and improved its structural similarity index (from 0.72 to 0.99). Hr96-CNN images ranked higher than Hr84-QIR3 and Hr96-QIR3 in overall quality (

conclusionsThe proposed CNN significantly reduced image noise in UHR PCD-CT, enabling the use of the sharpest kernel. This combination greatly enhanced diagnostic image quality and anatomic visualization.

Indexed as

Neural Networks, ComputerTemporal BoneTomography, X-Ray ComputedConvolutional Neural NetworksHumansPhotonsRadiographic Image Interpretation, Computer-AssistedSignal-To-Noise Ratio

Identifiers

PMID39528299
PMCPMC12152799

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.