SynthesiseNeuro2024
A Systematic Review and Meta-Analysis Assessing the Accuracy of Blood Biomarkers for the Diagnosis of Ischemic Stroke in Adult and Elderly Populations.
Synthesis in eNeuro, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
6 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Systematic review and meta-analysis of stroke blood biomarker data highlights need for more translational research methods.Nature communications · 2026Pooled it
- Diagnostic accuracy of circulating blood biomarker families in acute ischemic stroke: a secondary grouped meta-analysis with primary-study verification.Frontiers in neurology · 2026Pooled it
- Blood RNA Biomarker Signatures for Early Diagnosis and Prognosis in Ischemic and Hemorrhagic Stroke: The IBIS-CT1 Study.Annals of clinical and translational neurology · 2026Article
- Diagnostic performance of circulating microRNAs for the early diagnosis of different types of acute cerebrovascular disease.PloS one · 2026Article
- Influence of Isolation Techniques on the Quality of Plasma Samples: Implications for Cancer Biobanking.International journal of molecular sciences · 2025Article
- Emerging biomarkers in ischemic stroke.Vessel plus · 2025Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
This study aims to elucidate the methodology and compare the accuracy of different blood biomarkers for diagnosing ischemic stroke (IS). We reviewed 29 articles retrieved from PubMed, MEDLINE, Web of Science, and CINAHL Plus with Full Text. Among these, 23 articles involving 3,494 participants were suitable for meta-analysis. The pooled area under the curve (AUC) of all studies for meta-analysis was 0.89. The pooled sensitivity and specificity were 0.76 (0.74-0.78) and 0.84 (0.83-0.86), respectively. Blood biomarkers from noninpatient settings demonstrated better diagnostic performance than those in inpatient settings (AUC 0.91 vs 0.88). Smaller sample sizes (<100) showed better performance than larger ones (≥100; AUC 0.92 vs 0.86). Blood biomarkers from acute IS (AIS) patients showed higher diagnostic values than those from IS and other stroke types (AUC 0.91 vs 0.87). The diagnostic performance of multiple blood biomarkers was superior to that of a single biomarker (AUC 0.91 vs 0.88). The diagnostic value of blood biomarkers from Caucasians was higher than that from Asians and Africans (AUC 0.90 vs 0.89, 0.75). Blood biomarkers from those with comorbidities (AUC 0.92) showed a better diagnostic performance than those not reporting comorbidities (AUC 0.84). All the subgroups analyzed, including setting, sample size, target IS population, blood biomarker profiling, ethnicity, and comorbidities could lead to heterogeneity. Blood biomarkers have demonstrated sufficient diagnostic accuracy for diagnosing IS and hold promise for integration into routine clinical practice. However, further research is recommended to refine the optimal model for utilizing blood biomarkers in IS diagnosis.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.