ArticleActa paediatrica (Oslo, Norway : 1992)2025
Primary antibiotic prophylaxis in biliary atresia did not demonstrate decreased infection rate: Multi-centre retrospective study.
Article in Acta paediatrica (Oslo, Norway : 1992), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers, 1 of them a synthesis that pooled it.
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3 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Prophylactic oral antibiotic use for the prevention of cholangitis after Kasai portoenterostomy in patients with biliary atresia: a systematic review and meta-analysis.Frontiers in pediatrics · 2026Pooled it
- Primary antibiotic prophylaxis in biliary atresia did not demonstrate decreased infection rate: Multi-centre retrospective study.Acta paediatrica (Oslo, Norway : 1992) · 2025Article
- Biliary Atresia: advances and challenges in early diagnosis and management.Jornal de pediatriaReview
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7 authors.
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Abstract
aimThis retrospective study aimed to assess the efficacy of prophylactic antibiotics in preventing ascending cholangitis following Kasai portoenterostomy (KPE). Data from 72 patients treated across four tertiary centres in Israel from 2008 to 2018 were analysed.
methodsClinical and laboratory data were collected from biliary atresia (BA) diagnosis until liver transplantation (LT) or study completion.
resultsMedian age at KPE was 58.5 days. Successful KPE was achieved in 23 (32%) patients. Ascending cholangitis occurred in 6/23 (26%) successful KPE cases and 15/45 (33%) unsuccessful cases. Primary antibiotic prophylaxis (49% of patients) was associated with earlier onset of cholangitis (median 77 vs 239 days, p = 0.016). During follow-up, 39% underwent LT, with a 5-year survival with native liver (SNL) of 54%.
conclusionProphylactic antibiotics did not reduce cholangitis rates post-KPE in our cohort. Further research is essential to optimise management strategies for infants with BA.
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