Evidence map›Paper›PMID 39528164›Full record

ArticleJournal of the American Academy of Dermatology2025

Differentiating seborrheic keratosis from melanoma among lesions exhibiting blue-white veil: A retrospective study.

Isabella N Dana, Nicholas R Kurtansky, Larissa M Pastore, James R Xu, Zaeem H Nazir, Stephen W Dusza, Emmanouil Chousakos, Ofer Reiter, Cristian Navarrete-Dechent, Ralph P Braun and 2 more

Abstract read
In one paragraph

Article in Journal of the American Academy of Dermatology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Isabella N DanaDermatology Service, Memorial Sloan Kettering Cancer Center, New York, New York; SUNY Downstate Health Sciences University College of Medicine, Brooklyn, New York.
Nicholas R KurtanskyDermatology Service, Memorial Sloan Kettering Cancer Center, New York, New York.
Larissa M PastoreDermatology Service, Memorial Sloan Kettering Cancer Center, New York, New York; Cooper Medical School of Rowan University, Camden, New Jersey.
James R XuCase Western Reserve University School of Medicine, Cleveland, Ohio.
Zaeem H NazirDermatology Service, Memorial Sloan Kettering Cancer Center, New York, New York; Zucker School of Medicine at Hofstra/Northwell, Hempstead, New York.
Stephen W DuszaDermatology Service, Memorial Sloan Kettering Cancer Center, New York, New York.
Emmanouil ChousakosDepartment of Pathology, Medical School, National and Kapodistrian University of Athens, Athens, Greece.
Ofer ReiterDermatology Division, Rabin Medical Center, Petach Tikva, and Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel.
Cristian Navarrete-DechentDepartment of Dermatology, Pontificia Universidad Católica de Chile, Santiago, Chile.
Ralph P BraunDepartment of Dermatology, University Hospital Zurich, Zurich, Switzerland.
Harold S RabinovitzSkin and Cancer Associates, Plantation, Florida.
Ashfaq A MarghoobDermatology Service, Memorial Sloan Kettering Cancer Center, New York, New York. Electronic address: marghooa@mskcc.org.

Funding

X-RAY CRYSTALLOGRAPHYP30CA008748 · NCI · SLOAN-KETTERING INSTITUTE FOR CANCER RES · PI Nicholas D Socci · 1985 to 2026
$347.4M
NCI NIH HHS P30 CA008748
6 · The paper itself

Abstract

backgroundDifferentiating melanoma (MM) from seborrheic keratosis (SK) containing a blue-white veil (BWV) remains challenging.

objectiveIdentify dermoscopic features that can improve upon the differentiation between MMs and SKs exhibiting BWV.

methodsImages from 110 MMs and 121 SKs containing BWV were aggregated, and 91 MMs and 62 SKs from this data set had complete agreement on the presence of BWV according to 3 expert dermoscopists. Independent readers recorded the presence or absence of dermoscopic structures using a web-based data collection instrument. Odds ratios were used to evaluate the association between features and diagnosis, and Fisher's exact test was used to determine the significance of associations.

resultsThe combination of milia-like cysts and/or comedo-like openings (MCCO) within the BWV and BWV encompassing the entire lesion occurred in 56% of SKs and 0% of MM. All MMs had at least one MM-specific structure other than BWV or lacked MCCO. LIMITATIONS: Agreement on dermoscopic feature prevalence was variable. The subset of lesions with complete agreement on the presence of BWV may not be representative of lesions encountered in an individual clinician's practice.

conclusionLesions exhibiting BWV with MCCO and no additional MM-specific features suggest a benign diagnosis, as was not seen in any cases of MM.

Indexed as

Keratosis, SeborrheicMelanomaSkin NeoplasmsAgedDermoscopyDiagnosis, DifferentialFemaleHumansMaleMiddle AgedRetrospective Studiesblue-white veildermoscopymelanomaseborrheic keratosis

Identifiers

PMID39528164
PMCPMC11859760

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.