SynthesisRadiologie (Heidelberg, Germany)2024
Knee pain improvement after genicular artery embolization for the management of knee osteoarthritis: an updated systematic review and meta-analysis of 21 studies.
Synthesis in Radiologie (Heidelberg, Germany), 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
13 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Outcome and Safety of Genicular Artery Embolization for Knee Osteoarthritis: A Systematic Review and Meta-Analysis.Cardiovascular and interventional radiology · 2026Pooled it
- Transarterial Embolization in Osteoarthritis of the Knee: Mechanism of Action and Current Results.Deutsches Arzteblatt international · 2026Pooled it
- Multi-site efficacy and safety of transarterial microembolization with imipenem/cilastatin for refractory musculoskeletal pain: a single-centre analysis of hip, knee and shoulder (FIRE-NEM study).La Radiologia medica · 2026Article
- Genicular Artery Embolization for Chronic Exudative Knee Synovitis: Prospective 6-Month Clinical and Functional Outcomes.Journal of clinical medicine · 2026Article
- [Anatomy of the genicular arteries-What interventional radiologists should know].Radiologie (Heidelberg, Germany) · 2026Review
- Retrospective Comparison of Short- and Mid-Term Performance of 200-µm Polyethylene Glycol Microspheres vs Ethiodized Oil Emulsion for Genicular Artery Embolization in Symptomatic Knee Osteoarthritis.Cardiovascular and interventional radiology · 2026Article
- Segmentation of blush size guides embolic endpoints in genicular artery embolization.European radiology · 2026Article
- Repeated Genicular Artery Embolization Using Permanent Microspheres for Severe Osteoarthritis and Postsurgical Pain.Cardiovascular and interventional radiology · 2026Observational
- Transarterial embolization for chronic wrist pain: a preliminary study of feasibility, safety, and pain reduction.CVIR endovascular · 2026Article
- Genicular artery embolization for treating knee osteoarthritis - an overview of the evidence.Pain management · 2026Review
- Genicular Artery Embolization Using Resorbable Gelatin Microspheres for Refractory Knee Pain: Technique, Safety and Clinical Outcome.Cardiovascular and interventional radiology · 2026Observational
- Recent Advances in Therapeutic Approaches for Knee Osteoarthritis: a Narrative Review.Biomolecules & therapeutics · 2026Review
- Key Osteoarthritis Biomarkers: What Interventional Radiologists Performing Genicular Artery Embolization Need to Know.Cardiovascular and interventional radiology · 2025Review
Corrections and comments
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundKnee osteoarthritis is a progressive inflammatory musculoskeletal disease with a prevalence of approximately 15-23% and limited treatment options. In recent years, transcatheter genicular artery embolization (GAE) has been proposed due to promising results concerning symptomatic knee pain relief and mobility.
objectiveThis systematic review and meta-analysis aimed to evaluate the aggregated data on the safety and efficacy of GAE for pain reduction in the treatment of knee osteoarthritis. MATERIALS AND
methodsA systematic search of the three major databases (MEDLINE, Embase, and CENTRAL) from inception to 27 February 2024 was conducted according to the PRISMA guidelines. Studies reporting pain reduction according to the Visual Analogue Scale (VAS), Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC)-Total, WOMAC-Pain, and Knee Injury and Osteoarthritis Outcome Score (KOOS)-Pain scales and adverse event rates were included. Meta-analysis was performed by estimating the mean differences and by fitting random-effect models.
resultsOverall, 21 studies were included, comprising of 633 patients and 758 knees treated. The combined data analysis showed that patients who underwent GAE demonstrated mean declines in the VAS score of -38.5 points (95% confidence interval [CI]: -44.9, -32.0) at 1 month, -36.2 points (95% CI -43.0, -29.5) at 3 months, -40.3 points (95% CI: -49.0, -31.7) at 6 months, and -40.5 points (95% CI: -54.5, -26.6) at 12 months. Similarly, significant differences at all time points were also found for the WOMAC-Total, WOMAC-Pain, and KOOS-Pain scores. No difference between permanent and non-permanent embolic material was found in the subgroup analysis for all time points.
conclusionGenicular artery embolization is safe and effective for the treatment of painful knee osteoarthritis. This result was not affected by the type of embolic material used (permanent vs. non-permanent).
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Registered trials
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