Evidence map›Paper›PMID 39526973›Full record

Observational studyEpilepsia2025

Transition from pediatric to adult care system in patients with complex epilepsies: Necker model for transition evaluated on 70 consecutive patients.

Rima Nabbout, Agathe Molimard, Giovanna Scorrano, Melodie Aubart, Delphine Breuillard, Morgane Delaune, Giulia Barcia, Nicole Chemaly, Marie-Anne Barthez, Isabelle Desguerre

Abstract readObservational Study
PubMed Full text at PMC Publisher
In one paragraph

Observational study in Epilepsia, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed.

  1. Review
  2. Article
  3. Review
  4. Article
  5. Clinical insights on "delphi consensus funding on paediatric-adult transition: results from epilepsy transition working group of the Italian league against epilepsy (LICE)".Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2025
    Article
  6. Article
  7. Article
  8. Delphi consensus finding on paediatric-adult transition: results from the epilepsy transition working group of the italian league against epilepsy (LICE).Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2025
    Article
  9. Article
  10. Observational
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Rima NabboutReference Center for Rare Epilepsies, Department of Pediatric Neurology, Necker-Enfants Malades Hospital, APHP, member of European Reference Network EpiCARE, University of Paris Cité, Paris, France.
Agathe MolimardReference Center for Rare Epilepsies, Department of Pediatric Neurology, Necker-Enfants Malades Hospital, APHP, member of European Reference Network EpiCARE, University of Paris Cité, Paris, France.ORCID 0009-0003-3272-4425
Giovanna ScorranoReference Center for Rare Epilepsies, Department of Pediatric Neurology, Necker-Enfants Malades Hospital, APHP, member of European Reference Network EpiCARE, University of Paris Cité, Paris, France.
Melodie AubartReference Center for Rare Epilepsies, Department of Pediatric Neurology, Necker-Enfants Malades Hospital, APHP, member of European Reference Network EpiCARE, University of Paris Cité, Paris, France.
Delphine BreuillardReference Center for Rare Epilepsies, Department of Pediatric Neurology, Necker-Enfants Malades Hospital, APHP, member of European Reference Network EpiCARE, University of Paris Cité, Paris, France.ORCID 0009-0000-6317-900X
Morgane DelauneReference Center for Rare Epilepsies, Department of Pediatric Neurology, Necker-Enfants Malades Hospital, APHP, member of European Reference Network EpiCARE, University of Paris Cité, Paris, France.
Giulia BarciaImagine Institute, Laboratory of Translational Research for Neurological Disorders, INSERM UMR 1163, Paris, France.ORCID 0000-0001-6657-5040
Nicole ChemalyReference Center for Rare Epilepsies, Department of Pediatric Neurology, Necker-Enfants Malades Hospital, APHP, member of European Reference Network EpiCARE, University of Paris Cité, Paris, France.
Marie-Anne BarthezReference Center for Rare Epilepsies, Department of Pediatric Neurology, Necker-Enfants Malades Hospital, APHP, member of European Reference Network EpiCARE, University of Paris Cité, Paris, France.
Isabelle DesguerreReference Center for Rare Epilepsies, Department of Pediatric Neurology, Necker-Enfants Malades Hospital, APHP, member of European Reference Network EpiCARE, University of Paris Cité, Paris, France.

Funding

FAMA fund hosted by the SWISS Philantropic foundation ANR-10-IAHU-01FAMA fund hosted by the SWISS Philantropic foundation ANR-23-RHUS-0002
6 · The paper itself

Abstract

objectiveComplex epilepsies such as epileptic and developmental encephalopathies require multidisciplinary care throughout life. A coordinated transition program is therefore essential to provide optimal support for patients leaving pediatric for adult care. The aim of this study is to describe and evaluate our transition program for complex epilepsies, focusing on the last step in this program, that is, the multidisciplinary transition day hospital (MTDH).

methodsWe performed a retrospective observational study including patients with complex epilepsies who underwent the full steps of the transition program at Necker-Enfants Malades Hospital between May 2021 and June 2023, with a follow-up until February 2024. We described the cohort and detailed the interventions performed during the MTDH including medical, medicosocial, educational, daily life abilities, and laboratory and imaging assessments with the participation of one member of the adult team. We evaluated two indicators of our program: (1) the "adult first clinic attendance rate," defined by the percentage of patients attending their first adult clinic; and (2) the "return rate," defined by the percentage of patients who requested a pediatric encounter after their transfer.

resultsOur cohort included 70 patients with a mean age of 19.1 years (interquartile range = 16.3-19.5). Eighty percent had an epilepsy syndrome diagnosis; 72.8% were treated with three or more antiseizure medications. All patients had their appointment at the adult clinic within 6 months of the day hospital, and only two families requested a pediatric encounter after the transfer. SIGNIFICANCE: The transition program is key for an optimal transfer of patients with complex epilepsies to adult care. It requires a comprehensive multidisciplinary approach and provides a complete summary of the medical record. Our program secures a smooth landing in adult care and is a promising model to better manage the challenging transition process, especially in patients with complex epilepsy.

Indexed as

EpilepsyTransition to Adult CareAdolescentAdultChildFemaleHumansMaleRetrospective StudiesYoung AdultadolescentDEEsoutcometransitiontransition passport

Identifiers

PMID39526973
PMCPMC11742634

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.