Evidence map›Paper›PMID 39526929›Full record

ArticleEnvironmental science & technology2024

Insights into the Chemical Exposome during Pregnancy: A Non-Targeted Analysis of Preterm and Term Births.

Xiaowen Ji, Mathusa Lakuleswaran, Whitney Cowell, Linda G Kahn, Marina Sirota, Dimitri Abrahamsson

Abstract read
In one paragraph

Article in Environmental science & technology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Article
  2. Review
  3. Article
  4. Article
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  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Xiaowen JiDivision of Environmental Pediatrics, Department of Pediatrics, Grossman School of Medicine, New York University, New York, New York 10016, United States.ORCID 0000-0002-0507-7520
Mathusa LakuleswaranDivision of Environmental Pediatrics, Department of Pediatrics, Grossman School of Medicine, New York University, New York, New York 10016, United States.
Whitney CowellDivision of Environmental Pediatrics, Department of Pediatrics, Grossman School of Medicine, New York University, New York, New York 10016, United States.
Linda G KahnDivision of Environmental Pediatrics, Department of Pediatrics, Grossman School of Medicine, New York University, New York, New York 10016, United States.
Marina SirotaBakar Computational Health Sciences Institute, UCSF, San Francisco, California 94158, United States.
Dimitri AbrahamssonDivision of Environmental Pediatrics, Department of Pediatrics, Grossman School of Medicine, New York University, New York, New York 10016, United States.ORCID 0000-0002-3402-7565

Funding

The NYU Children’s Health & Environment Study: an ECHO CohortUG3OD023305 · OD · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI TRASANDE, LEONARDO · 2016 to 2024
$26.5M
UCSF Environmental Research and Translation for Health Center (EaRTH Center)P30ES030284 · NIEHS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI Rashmi Joglekar · 2020 to 2026
$11.2M
Nonpersistent chemical exposure, placental development, and maternal pre- and post-pregnancy cardiovascular healthR00ES030403 · NIEHS · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI KAHN, LINDA G · 2022 to 2024
$746k
Particulate air pollution, pregnancy outcomes, and the role of placental extracellular microRNAsR00ES032029 · NIEHS · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI COWELL, WHITNEY · 2022 to 2024
$745k
Non-target analysis of maternal and cord blood samples: Advancing computational tools and discovering novel chemicalsR00ES032892 · NIEHS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI ABRAHAMSSON, DIMITRI · 2023 to 2025
$745k
Non-target analysis of maternal and cord blood samples: Advancing computational tools and discovering novel chemicalsK99ES032892 · NIEHS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI ABRAHAMSSON, DIMITRI · 2021 to 2022
$200k
NIEHS NIH HHS K99 ES032892NIEHS NIH HHS P30 ES030284NIEHS NIH HHS R00 ES030403NIEHS NIH HHS R00 ES032029NIEHS NIH HHS R00 ES032892NIH HHS UG3 OD023305
6 · The paper itself

Abstract

Human-made chemicals are ubiquitous, leading to chronic exposure to complex mixtures of potentially harmful substances. We investigated chemical exposures in pregnant women in New York City by applying a non-targeted analysis (NTA) workflow to 95 paired prenatal urine and serum samples (35 pairs of preterm birth) collected as part of the New York University Children's Health and Environment Study. We analyzed all samples using liquid chromatography coupled with Orbitrap high-resolution mass spectrometry in both positive and negative electrospray ionization modes, employing full scan and data-dependent MS/MS fragmentation scans. We detected a total of 1524 chemical features for annotation, with 12 chemicals confirmed by authentic standards. Two confirmed chemicals dodecyltrimethylammonium and

Indexed as

Premature BirthAdultExposomeFemaleHumansInfant, NewbornPregnancyTerm Birthchemical associationsexogenous chemicalsexposurehigh-resolution mass spectrometrynon-targeted analysispreterm birth

Identifiers

PMID39526929
PMCPMC11603774

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.