Evidence map›Paper›PMID 39526754›Full record

ArticleMicrobiology spectrum2024

Physiological oxygen concentration during sympathetic primary neuron culture improves neuronal health and reduces HSV-1 reactivation.

Sara A Dochnal, Patryk A Krakowiak, Abigail L Whitford, Anna R Cliffe

Abstract read
In one paragraph

Article in Microbiology spectrum, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Human Dorsal Root Ganglia Neuronal Cell Line to Study Nociceptive Signaling: A New Pipeline for Pain Therapy.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2026
    Article
  2. Article
  3. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

4 authors.

Sara A DochnalDepartment of Microbiology, Immunology and Cancer Biology, University of Virginia, Charlottesville, Virginia, USA.ORCID 0000-0003-3011-567X
Patryk A KrakowiakDepartment of Microbiology, Immunology and Cancer Biology, University of Virginia, Charlottesville, Virginia, USA.
Abigail L WhitfordDepartment of Microbiology, Immunology and Cancer Biology, University of Virginia, Charlottesville, Virginia, USA.
Anna R CliffeDepartment of Microbiology, Immunology and Cancer Biology, University of Virginia, Charlottesville, Virginia, USA.

Funding

INFECTIOUS DISEASES TRAINING PROGRAMT32AI007046 · NIAID · UNIVERSITY OF VIRGINIA CHARLOTTESVILLE · PI Alison K Criss, William A Petri · 1985 to 2026
$15.3M
TRAINING IN CELL AND MOLECULAR BIOLOGYT32GM008136 · NIGMS · UNIVERSITY OF VIRGINIA CHARLOTTESVILLE · PI STUKENBERG, P. TODD · 1985 to 2020
$8.5M
Cell stress-mediated changes in the Herpes simplex virus type 1 chromatin structure during reactivation from latent infectionR01NS105630 · NINDS · UNIVERSITY OF VIRGINIA · PI CLIFFE, ANNA RUTH · 2018 to 2022
$1.8M
HHS | National Institutes of Health (NIH) NS105630HHS | National Institutes of Health (NIH) T32AI007046HHS | National Institutes of Health (NIH) T32GM008136NIAID NIH HHS T32 AI007046NIGMS NIH HHS T32 GM008136NINDS NIH HHS R01 NS105630Owens Family Foundation (The Owens Family Foundation)
6 · The paper itself

Abstract

Herpes simplex virus-1 (HSV-1) establishes a latent infection in peripheral neurons and periodically reactivates in response to a stimulus to permit transmission.

Indexed as

Herpesvirus 1, HumanNeuronsOxygenVirus ActivationAnimalsCells, CulturedHerpes SimplexHumansVirus LatencyOxygenherpes simplex virusin vitro culturelatencyoxygenreactivationsympathetic neurons

Identifiers

PMID39526754
PMCPMC11619363

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.