Evidence map›Paper›PMID 39526563›Full record

Observational studyJournal of pediatric gastroenterology and nutrition2025

The association of human milk intake and outcomes in biliary atresia.

Mary Elizabeth M Tessier, Jeremy M Schraw, Stacey Beer, Sanjiv Harpavat, M Kyle Jensen, John C Magee, Vicky Ng, Michael E Scheurer, Sarah A Taylor, Benjamin L Shneider

Registry-linked trialAbstract readObservational Study
PubMed Full text at PMC Publisher
In one paragraph

Observational study in Journal of pediatric gastroenterology and nutrition, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT00061828 (Childhood Liver Disease Research Network), which is not on this map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT00061828 recruitingnot on this map

Childhood Liver Disease Research Network (ChiLDReN): A Prospective Database of Infants With Cholestasis

TypeobservationalSponsorArbor Research Collaborative for HealthRan2004 to 2029Enrolled1,000ConditionsBiliary Atresia
3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Review
  3. Gut microbiome in biliary atresia.World journal of pediatric surgery · 2026
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Mary Elizabeth M TessierDepartment of Pediatrics, Baylor College of Medicine, Texas Children's Hospital, Section of Pediatric Gastroenterology Hepatology and Nutrition, Houston, Texas, USA.ORCID 0000-0002-0341-5442
Jeremy M SchrawDepartment of Pediatrics, Division of Hematology/Oncology, Baylor College of Medicine, Texas Children's Hospital, Houston, Texas, USA.
Stacey BeerDepartment of Pediatrics, Baylor College of Medicine, Texas Children's Hospital, Section of Pediatric Gastroenterology Hepatology and Nutrition, Houston, Texas, USA.
Sanjiv HarpavatDepartment of Pediatrics, Baylor College of Medicine, Texas Children's Hospital, Section of Pediatric Gastroenterology Hepatology and Nutrition, Houston, Texas, USA.
M Kyle JensenDepartment of Pediatrics, Pediatric Gastroenterology, Hepatology and Nutrition, Primary Children's Hospital, University of Utah, Salt Lake City, Utah, USA.
John C MageeDepartment of Surgery, University of Michigan Hospitals and Health Centers, Ann Arbor, Michigan, USA.
Vicky NgDivision of Pediatric Gastroenterology, Hepatology and Nutrition, The Hospital for Sick Children, University of Toronto, Toronto, Ontario, Canada.
Michael E ScheurerDepartment of Pediatrics, Division of Hematology/Oncology, Baylor College of Medicine, Texas Children's Hospital, Houston, Texas, USA.
Sarah A TaylorDepartment of Pediatrics, Division of Gastroenterology Hepatology and Nutrition, Children's Hospital Colorado and University of Colorado School of Medicine, Aurora, Colorado, USA.
Benjamin L ShneiderDepartment of Pediatrics, Baylor College of Medicine, Texas Children's Hospital, Section of Pediatric Gastroenterology Hepatology and Nutrition, Houston, Texas, USA.

Funding

Childhood Liver Disease Research Network Data Coordinating CenterU01DK062456 · NIDDK · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI MAGEE, JOHN C, MERION, ROBERT M · 2002 to 2019
$36.8M
Childhood Liver Disease Research Network Data Coordinating CenterU24DK062456 · NIDDK · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI JOHN C MAGEE · 2019 to 2026
$18.9M
Etiology and Treatment of Biliary Atresia and INHU01DK062453 · NIDDK · UNIVERSITY OF COLORADO DENVER · PI RONALD J. SOKOL · 2002 to 2026
$13.5M
Clinical Center for Cholestatic Liver Disease in ChildrenU01DK062497 · NIDDK · CINCINNATI CHILDRENS HOSP MED CTR · PI Alexander Miethke · 2002 to 2026
$13.2M
Macrophage Cell Subset Specific Biomarkers for Disease Prognosis in Biliary AtresiaU01DK062436 · NIDDK · LURIE CHILDREN'S HOSPITAL OF CHICAGO · PI ALONSO, ESTELLA M. · 2002 to 2023
$7.0M
Intermountain West Clinical Center for a Childhood Liver Disease Research NetworkU01DK103140 · NIDDK · UTAH STATE HIGHER EDUCATION SYSTEM--UNIVERSITY OF UTAH · PI Stephen L Guthery · 2014 to 2026
$5.2M
Clinical Center for ChiLDREN: Pathogenesis, Biomarkers, and Antifibrotic TherapyU01DK103149 · NIDDK · BAYLOR COLLEGE OF MEDICINE · PI BENJAMIN L SHNEIDER · 2014 to 2026
$4.8M
Understanding Cholestatic Disorders in a Collaborative Network: The Role of SickKU01DK103135 · NIDDK · HOSPITAL FOR SICK CHLDRN (TORONTO) · PI KAMATH, BINITA MAYA · 2014 to 2018
$1.0M
A multi-center study of the microbiome in biliary atresiaK23DK119567 · NIDDK · BAYLOR COLLEGE OF MEDICINE · PI TESSIER, MARY ELIZABETH MCCONNELL · 2021 to 2025
$926k
Children's Hospital Colorado U01DK062453ChiLDReN's Scientific Data Coordinating Center, Ann Arbor, MI U24DK062456National Institute of Diabetes, Digestive and Kidney Diseases 5K23-DK119567NIDDK NIH HHS K23 DK119567NIDDK NIH HHS U01 DK062436NIDDK NIH HHS U01 DK062453NIDDK NIH HHS U01 DK062456NIDDK NIH HHS U01 DK062497NIDDK NIH HHS U01 DK103135NIDDK NIH HHS U01 DK103140NIDDK NIH HHS U01 DK103149NIDDK NIH HHS U24 DK062456Texas Children's Hospital U01DK103149The Hospital for Sick Children U01DK103135The University of Michigan U01DK062456University of Utah U01DK103140
6 · The paper itself

Abstract

objectivesHuman milk intake has many benefits which could influence outcomes in biliary atresia (BA). However, the role of human milk in BA has not been examined. We hypothesized that human milk intake would be associated with improved outcomes in BA.

methodsWe assessed the impact of any human milk (AHM) as compared to formula only (FO) intake before Kasai portoenterostomy (KP) on outcomes in 447 infants with BA using the PROBE database (NCT00061828) post hoc. The primary outcome was clearance of jaundice (COJ = total bilirubin (TB) < 2 mg/dL by 3 months post-KP). Secondary outcomes included 2-year survival with native liver (SNL), bilirubin levels, cholangitis, ascites, and growth. We assessed the fecal microbiome (n = 8) comparing AHM versus FO.

resultsAt baseline, 211 infants received AHM and 215 received FO. 53.9% of AHM and 50.5% of FO achieved COJ (p = NS). SNL was insignificantly increased in AHM (odds ratio = 1.47, 95% confidence interval: 1.00-2.12, p = 0.053). TB decreased in AHM from 4 weeks to 3 months post-KP [4.8-4.0 mg/dL (p = 0.01)] unlike the FO group (4.9-4.9 mg/dL, p = 0.4). At 3 months post-KP, AHM infants had greater weight gain (1.88 ± 0.66 vs. 1.57 ± 0.73 kg, p < 0.001) and mid-upper arm circumference (12.9 ± 1.4 vs. 12.2 ± 1.7 cm, p < 0.001). Other secondary outcomes were not different. Microbiome differences were seen between AHM and FO.

conclusionsHuman milk intake in infants with BA did not significantly improve COJ or SNL. However, growth parameters were improved, and TB 3 months post-KP was decreased. Thus, human milk intake should not be discouraged. Prospective studies with detailed assessment of human milk intake are needed.

Indexed as

Biliary AtresiaInfant FormulaMilk, HumanPortoenterostomy, HepaticFemaleHumansInfantInfant, NewbornMaleTreatment Outcomecholestasisliver transplantnutrition

Identifiers

PMID39526563
PMCPMC11863988

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.