Evidence map›Paper›PMID 39526313›Full record

ReviewJournal of ultrasound in medicine : official journal of the American Institute of Ultrasound in Medicine2025

Overview of Therapeutic Ultrasound Applications and Safety Considerations: 2024 Update.

Kenneth B Bader, Frederic Padilla, Kevin J Haworth, Nicholas Ellens, Diane Dalecki, Douglas L Miller, Keith A Wear, Bioeffects Committee of the American Institute of Ultrasound in Medicine

Abstract readReview
In one paragraph

Review in Journal of ultrasound in medicine : official journal of the American Institute of Ultrasound in Medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
28citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

28 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Article
  3. Article
  4. Supramolecular Degraders: An Emerging Paradigm in Targeted Protein Degradation.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026
    Review
  5. Review
  6. Ultrasound-responsive composite hydrogels: Design rules for spatiotemporally controlled drug delivery.Journal of controlled release : official journal of the Controlled Release Society · 2026
    Review
  7. Review
  8. Article
  9. Sono-Mechanogenetics: Linking Ultrasound Physics With Cellular Mechanobiology.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026
    Review
  10. Article
  11. Article
  12. Article
  13. Review
  14. Enhancing dromedary camel (Frontiers in veterinary science · 2026
    Review
  15. Review
  16. Review
  17. Article
  18. Article
  19. Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Kenneth B BaderDepartment of Radiology, University of Chicago, Chicago, Illinois, USA.ORCID https://orcid.org/0000-0003-2384-3150
Frederic PadillaGene Therapy Program, Focused Ultrasound Foundation, Charlottesville, Virginia, USA.
Kevin J HaworthDepartment of Pediatrics, University of Cincinnati, Cincinnati, Ohio, United States.ORCID https://orcid.org/0000-0002-6578-2440
Nicholas EllensAlpheus Medical, Inc., Chanhassen, Minnesota, USA.
Diane DaleckiDepartment of Biomedical Engineering, University of Rochester, Rochester, New York, USA.
Douglas L MillerDepartment of Radiology, University of Michigan Health System, Ann Arbor, Michigan, USA.
Keith A WearCenter for Devices and Radiological Health, U.S. Food and Drug Administration, Silver Spring, Maryland, USA.
Bioeffects Committee of the American Institute of Ultrasound in Medicine

Funding

Treatment of chronic venous thrombosis with histotripsy and thrombolyticsR01HL133334 · NHLBI · UNIVERSITY OF CHICAGO · PI Kenneth B. Bader · 2018 to 2026
$5.7M
Ultrasound-mediated Controlled Hypoxemic Reperfusion for Inhibition of Reperfusion InjuryR01HL148451 · NHLBI · UNIVERSITY OF CINCINNATI · PI HAWORTH, KEVIN JOSEPH · 2019 to 2023
$3.7M
Imaging Feedback for Histotripsy Renal Tumor AblationR01EB035230 · NIBIB · UNIVERSITY OF CHICAGO · PI Kenneth B. Bader · 2024 to 2026
$1.2M
American Cancer Society RSG-21-171-01-ETChildren's Neuroblastoma Cancer FoundationFocused Ultrasound FoundationNational Science Foundation 2426784NHLBI NIH HHS R01 HL133334NHLBI NIH HHS R01 HL148451NIBIB NIH HHS R01 EB035230NIH HHS R01 EB0352309NIH HHS R01 HL133334NIH HHS R01 HL148451
6 · The paper itself

Abstract

A 2012 review of therapeutic ultrasound was published to educate researchers and physicians on potential applications and concerns for unintended bioeffects (doi: 10.7863/jum.2012.31.4.623). This review serves as an update to the parent article, highlighting advances in therapeutic ultrasound over the past 12 years. In addition to general mechanisms for bioeffects produced by therapeutic ultrasound, current applications, and the pre-clinical and clinical stages are outlined. An overview is provided for image guidance methods to monitor and assess treatment progress. Finally, other topics relevant for the translation of therapeutic ultrasound are discussed, including computational modeling, tissue-mimicking phantoms, and quality assurance protocols.

Indexed as

Patient SafetyUltrasonic TherapyHumansbioeffectsimage‐guided therapytherapeutic ultrasound

Identifiers

PMID39526313
PMCPMC11796337

What OpenQuestion holds

Textmetadata
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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.