ArticleJournal of medical physics
Composite Iodine-gold Nanoparticles as a Contrast Agent in Computed Tomography.
Article in Journal of medical physics. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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7 authors.
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Abstract
Purpose: Solutions of iodine-based compounds, due to their high X-ray attenuation coefficient, are widely used as contrast agents in computed tomography (CT) imaging. This paper investigates the attenuation properties of iodine and gold to develop nanoparticle-based contrast agents, for example, composite nanoparticles (NPs) with layers of iodine and gold or a mixture of NPs of gold and iodine. Materials and Methods: A theoretical formula is derived that gives the Hounsfield Unit (HU) for different weight-by-weight (w/w) concentrations of a mixture of blood + iodine + gold. The range of compositions for which iodine + gold mixture can give a suitable HU ≥ Results: It is seen that for an aqueous solution of iodine, the suitable HU of 250 (hence giving sufficient gray level to the CT image) can be obtained with w/w concentrations of iodine being 0.0044, 0.008, and 0.0097 for observations at 80, 100, and 120 kVp, respectively. The corresponding w/w concentrations of gold NPs would be 0.0103, 0.0131, and 0.0158. With these basic results, compositions of suitable mixtures of iodine and gold are also specified. Conclusion: Aqueous suspensions of gold NPs are suitable as contrast materials for CT imaging and can also be used as a component of a composite contrast material consisting of an iodine and gold mixture.
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