Evidence map›Paper›PMID 39526111›Full record

ArticleBrain circulation

Investigation of neuroprotective effects of H

Yan Feng, Chuanjie Wu, Baoying Song, Yang Zhang, Miaowen Jiang, Zhengfei Qi, Le Chen, Anzhi Li, Hanming Ye, Biluo Liu and 4 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Brain circulation. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Yan Feng *Department of Neurology, Suzhou Hospital of Anhui Medical University, Hefei, Anhui, China.
Chuanjie Wu *Department of Neurology, Beijing Institute of Geriatrics , Xuanwu Hospital, Capital Medical University, Beijing, China.
Baoying SongDepartment of Neurology, Beijing Institute of Geriatrics , Xuanwu Hospital, Capital Medical University, Beijing, China.
Yang ZhangDepartment of Neurology, Beijing Institute of Geriatrics , Xuanwu Hospital, Capital Medical University, Beijing, China.
Miaowen JiangDepartment of Neurology, Beijing Institute for Brain Disorders, Capital Medical University, Beijing, China.
Zhengfei QiDepartment of Neurology, Beijing Institute for Brain Disorders, Capital Medical University, Beijing, China.
Le ChenDepartment of Neurology, Suzhou Hospital of Anhui Medical University, Hefei, Anhui, China.
Anzhi LiDepartment of Neurology, Suzhou Hospital of Anhui Medical University, Hefei, Anhui, China.
Hanming YeDepartment of Neurology, Suzhou Hospital of Anhui Medical University, Hefei, Anhui, China.
Biluo LiuDepartment of Neurology, Suzhou Hospital of Anhui Medical University, Hefei, Anhui, China.
Yu FengDepartment of Neurology, Affiliated Hospital of Xuzhou Medical University, Xuzhou, Jiangsu, China.
Xunming JiDepartment of Neurology, Beijing Institute of Geriatrics , Xuanwu Hospital, Capital Medical University, Beijing, China.
Zhengfei Ma *Department of Neurology, Suzhou Hospital of Anhui Medical University, Hefei, Anhui, China.
Ming Li *Department of Neurology, Beijing Institute of Geriatrics , Xuanwu Hospital, Capital Medical University, Beijing, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

BACKGROUND AND

aimsNeuroprotection plays an important role in the treatment of brain disorders. In recent years, studies using rat models and clinical trials have demonstrated the positive effects of hydrogen treatment on neurological disorders and brain injuries. Hence, it is of great significance to shed light on this issue. In this article, CiteSpace is employed for visualization and bibliometric analysis of the research frontiers and evolving trends related to the neuroprotective effect of hydrogen.

methodsAll articles published from 2009 to 2023 that discussed the neuroprotective effects of hydrogen in cerebrovascular diseases were retrieved from the Web of Science. Using CiteSpace, a visualization analysis was conducted on aspects such as countries, institutions, authors, keywords, and Co cited references, which enables an intuitive observation of current research hotspots.

resultsAfter manual screening, a total of 106 articles were retrieved. Over time, The number of publications has increased annually. Regarding national contributions, the top three countries with the highest number of publications include China, the United States, and Japan. The Second Military Medical University is the institution that publishes the most articles and has significant influence in the field of hydrogen neuroprotection. Sun, Xuejun and Domoki, Ferenc were the most productive. The most common keywords include hydrogen, oxidative stress, inflammation, and apoptosis. Potential areas of focus for future research consist of early brain injury, hydrogen, ischemia-reperfusion injury and hypothermia treatment.

conclusionThe bibliometric study presented herein offers insights into the current status and trends of research on hydrogen in the field of cerebrovascular diseases. Future research trends suggest that hydrogen contributes significantly to the cerebrovascular domain through its anti-inflammatory, antioxidative, and anti-apoptotic mechanisms. This study can aid researchers in identifying hot topics and exploring new research directions.

Indexed as

ApoptosisCiteSpacehydrogenhypothermia treatmentinflammationneurological diseasesneuroprotectionoxidative stress

Identifiers

PMID39526111
PMCPMC11542759

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-SA
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.