Evidence map›Paper›PMID 39525958›Full record

ReviewCurrent research in microbial sciences2024

Insights into the unique roles of extracellular vesicles for gut health modulation: Mechanisms, challenges, and perspectives.

Qiming Wu, Juntao Kan, Caili Fu, Xin Liu, Zhengying Cui, Sixu Wang, Yi Le, Zhanming Li, Qin Liu, Yuyu Zhang and 1 more

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Current research in microbial sciences, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.

0numbers the graph read from it
0cells of the map it votes in
26citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

26 citing papers in PubMed.

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  10. Aging-Driven Inter-Organ Crosstalk in Postmenopausal Osteoporosis: From Immunometabolic Drift to Multisystem Frailty.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2026
    Review
  11. Review
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  14. Microbial extracellular vesicles in the lung: friends in health, agents in disease.Extracellular vesicles and circulating nucleic acids · 2026
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Qiming WuNutrilite Health Institute, Shanghai 200031, China.
Juntao KanNutrilite Health Institute, Shanghai 200031, China.
Caili FuDepartment of Food Science and Technology, National University of Singapore Suzhou Research Institute, Suzhou 215123, China.
Xin LiuDepartment of Food Science and Technology, National University of Singapore Suzhou Research Institute, Suzhou 215123, China.
Zhengying CuiDepartment of Food Science and Technology, National University of Singapore Suzhou Research Institute, Suzhou 215123, China.
Sixu WangDepartment of Food Science and Technology, National University of Singapore Suzhou Research Institute, Suzhou 215123, China.
Yi LeDepartment of Food Science and Technology, National University of Singapore Suzhou Research Institute, Suzhou 215123, China.
Zhanming LiDepartment of Food Quality and Safety, Jiangsu University of Science and Technology, Zhenjiang 212100, China.
Qin LiuCentre for Chinese Medicine Drug Development Limited, Hong Kong Baptist University, 999077, Hong Kong Special Administrative Region of China.
Yuyu ZhangKey Laboratory of Geriatric Nutrition and Health, Beijing Technology and Business University, Beijing 100048, China.
Jun DuNutrilite Health Institute, Shanghai 200031, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Extracellular vesicles (EVs), which play significant regulatory roles in maintaining homeostasis and influencing immune responses, significantly impact gut microbiota composition and function, affecting overall gut health. Despite considerable progress, there are still knowledge gaps regarding the mechanisms by which EVs, including plant-derived EVs (PDEVs), animal-derived EVs (ADEVs), and microbiota-derived EVs (MDEVs), modulate gut health. This review delves into the roles and mechanisms of EVs from diverse sources in regulating gut health, focusing on their contributions to maintaining epithelial barrier integrity, facilitating tissue healing, eliciting immune responses, controlling pathogens, and shaping microbiota. We emphasize open challenges and future perspectives for harnessing EVs in the modulation of gut health to gain a deeper understanding of their roles and impact. Importantly, a comprehensive research framework is presented to steer future investigations into the roles and implications of EVs on gut health, facilitating a more profound comprehension of this emerging field.

Indexed as

Extracellular vesiclesGut barrierGut healthImmune responsesMicrobiota

Identifiers

PMID39525958
PMCPMC11550031

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.