Evidence map›Paper›PMID 39525804›Full record

ArticleBioactive materials2025

Cell driven elastomeric particle packing in composite bioinks for engineering and implantation of stable 3D printed structures.

Shira Landau, Jennifer Kieda, Ramak Khosravi, Sargol Okhovatian, Kaitlyn Ramsay, Chuan Liu, Amid Shakeri, Yimu Zhao, Karen Shen, Orit Bar-Am and 3 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Bioactive materials, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Review
  2. Article
  3. Article
  4. Application and progress of 3D printed biomaterials in osteoporosis.Frontiers in bioengineering and biotechnology · 2025
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Shira LandauUniversity of Toronto, Institute of Biomedical Engineering, Toronto, ON, Canada.
Jennifer KiedaUniversity of Toronto, Institute of Biomedical Engineering, Toronto, ON, Canada.
Ramak KhosraviUniversity Health Network, Toronto General Hospital Research Institute, Toronto, ON, Canada.
Sargol OkhovatianUniversity of Toronto, Institute of Biomedical Engineering, Toronto, ON, Canada.
Kaitlyn RamsayUniversity of Toronto, Institute of Biomedical Engineering, Toronto, ON, Canada.
Chuan LiuUniversity of Toronto, Institute of Biomedical Engineering, Toronto, ON, Canada.
Amid ShakeriUniversity of Toronto, Institute of Biomedical Engineering, Toronto, ON, Canada.
Yimu ZhaoUniversity of Toronto, Institute of Biomedical Engineering, Toronto, ON, Canada.
Karen ShenUniversity of Toronto, Institute of Biomedical Engineering, Toronto, ON, Canada.
Orit Bar-AmFaculty of Biomedical Engineering, Technion, Haifa, IL, Israel.
Shulamit LevenbergFaculty of Biomedical Engineering, Technion, Haifa, IL, Israel.
Scott TsaiToronto Metropolitan University, Department of Mechanical, Industrial, and Mechatronics Engineering, Toronto, ON, Canada.
Milica RadisicUniversity of Toronto, Institute of Biomedical Engineering, Toronto, ON, Canada.

Funding

Engineering Vascularized Cardiac MuscleR01HL076485 · NHLBI · COLUMBIA UNIV NEW YORK MORNINGSIDE · PI Gordana Vunjak-Novakovic · 2005 to 2026
$9.2M
NHLBI NIH HHS R01 HL076485
6 · The paper itself

Abstract

Geometric and structural integrity often deteriorate in 3D printed cell-laden constructs over time due to cellular compaction and hydrogel shrinkage. This study introduces a new approach that synergizes the advantages of cell compatibility of biological hydrogels and mechanical stability of elastomeric polymers for structure fidelity maintenance upon stereolithography and extrusion 3D printing. Enabling this advance is the composite bioink, formulated by integrating elastomeric microparticles from poly(octamethylene maleate (anhydride) citrate) (POMaC) into biologically derived hydrogels (fibrin, gelatin methacryloyl (GelMA), and alginate). The composite bioink enhanced the elasticity and plasticity of the 3D printed constructs, effectively mitigating tissue compaction and swelling. It exhibited a low shear modulus and a rapid crosslinking time, along with a high ultimate compressive strength and resistance to deformation from cellular forces and physical handling; this was attributed to packing and stress dissipation of elastomeric particles, which was confirmed via mathematical modelling. Enhanced functional assembly and stability of human iPSC-derived cardiac tissues and primary vasculature proved the utility of the composite bioink in tissue engineering.

Indexed as

3D printingBioinkCardiacDroplet microfluidicsElastomerGranular materialParticlePolymerVascular

Identifiers

PMID39525804
PMCPMC11550138

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.