Evidence map›Paper›PMID 39525621›Full record

ReviewFrontiers in oncology2024

Obesity and lack of breastfeeding: a perfect storm to augment risk of breast cancer?

Kate Ormiston, Anagh Kulkarni, Gautam Sarathy, Sara Alsammerai, Eswar Shankar, Sarmila Majumder, Kristin I Stanford, Ramesh K Ganju, Bhuvaneswari Ramaswamy

Abstract readReview
In one paragraph

Review in Frontiers in oncology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Kate OrmistonDivision of Medical Oncology, The Ohio State University Comprehensive Cancer Center, Columbus, OH, United States.
Anagh KulkarniDivision of Medical Oncology, The Ohio State University Comprehensive Cancer Center, Columbus, OH, United States.
Gautam SarathyDivision of Medical Oncology, The Ohio State University Comprehensive Cancer Center, Columbus, OH, United States.
Sara AlsammeraiDivision of Medical Oncology, The Ohio State University Comprehensive Cancer Center, Columbus, OH, United States.
Eswar ShankarDivision of Medical Oncology, The Ohio State University Comprehensive Cancer Center, Columbus, OH, United States.
Sarmila MajumderDivision of Medical Oncology, The Ohio State University Comprehensive Cancer Center, Columbus, OH, United States.
Kristin I StanfordDorothy M. Davis Heart and Lung Research Institute, Department of Surgery, Division of General and Gastrointestinal Surgery, The Ohio State University Wexner Medical Center, Columbus, OH, United States.
Ramesh K GanjuDepartment of Pathology, The Ohio State University Comprehensive Cancer Center, Columbus, OH, United States.
Bhuvaneswari RamaswamyDivision of Medical Oncology, The Ohio State University Comprehensive Cancer Center, Columbus, OH, United States.

Funding

Regional Pilot And Feasibility Study Grants ProgramP30DK020572 · NIDDK · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI Mehboob A Hussain · 2013 to 2026
$24.3M
Unravel the novel role of S100A7 and its functional partners in Metastatic Triple Negative Breast Cancer Racial DisparityR01CA292020 · NCI · OHIO STATE UNIVERSITY · PI Ramesh K. Ganju · 2024 to 2026
$2.3M
Addressing cancer disparity through defining the molecular link between breast feeding and triple negative breast cancerR01CA231857 · NCI · OHIO STATE UNIVERSITY · PI GANJU, RAMESH K., STOVER, DANIEL G. · 2019 to 2023
$2.2M
NCI NIH HHS R01 CA231857NCI NIH HHS R01 CA292020NIDDK NIH HHS P30 DK020572
6 · The paper itself

Abstract

Triple-negative breast cancer (TNBC) is one of the most aggressive subtypes of breast cancer with higher rates of recurrence and distant metastasis, as well as decreased 5-year survival rates. Racial disparities are evident in the incidence and mortality rates of triple negative breast cancer particularly increased in young African American women. Concurrently, young African American women have multiple risk factors for TNBC including higher rates of premenopausal abdominal obesity (higher waist-hip ratio) and lower rates of breastfeeding with higher parity, implicating these factors as potentially contributors to poor outcomes. By understanding the mechanisms of how premenopausal obesity and lack of breastfeeding may be associated with increased risk of triple negative breast cancer, we can determine the best strategies for intervention and awareness to improve outcomes in TNBC.

Indexed as

breastfeedinginvolutionobesityracial disparitiestriple negative breast cancer

Identifiers

PMID39525621
PMCPMC11543574

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.