Evidence map›Paper›PMID 39525580›Full record

ArticleActa pharmaceutica Sinica. B2024

Ribonucleotide reductase small subunit M2 promotes the proliferation of esophageal squamous cell carcinoma cells

Jing Zhang, Qiong Wu, Yifei Xie, Feng Li, Huifang Wei, Yanan Jiang, Yan Qiao, Yinhua Li, Yanan Sun, Han Huang and 4 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Acta pharmaceutica Sinica. B, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Exploratory transcriptomics andBiomedical reports · 2026
    Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Jing ZhangPathophysiology Department, School of Basic Medical Sciences, Zhengzhou University, Zhengzhou 450000, China.
Qiong WuPathophysiology Department, School of Basic Medical Sciences, Zhengzhou University, Zhengzhou 450000, China.
Yifei XiePathophysiology Department, School of Basic Medical Sciences, Zhengzhou University, Zhengzhou 450000, China.
Feng LiThe First Affiliated Hospital of Zhengzhou University, Zhengzhou 450000, China.
Huifang WeiPathophysiology Department, School of Basic Medical Sciences, Zhengzhou University, Zhengzhou 450000, China.
Yanan JiangPathophysiology Department, School of Basic Medical Sciences, Zhengzhou University, Zhengzhou 450000, China.
Yan QiaoPathophysiology Department, School of Basic Medical Sciences, Zhengzhou University, Zhengzhou 450000, China.
Yinhua LiThe First Affiliated Hospital of Zhengzhou University, Zhengzhou 450000, China.
Yanan SunPathophysiology Department, School of Basic Medical Sciences, Zhengzhou University, Zhengzhou 450000, China.
Han HuangPathophysiology Department, School of Basic Medical Sciences, Zhengzhou University, Zhengzhou 450000, China.
Mengmeng GeChina-US (Henan) Hormel Cancer Institute, Zhengzhou 450000, China.
Dengyun ZhaoPathophysiology Department, School of Basic Medical Sciences, Zhengzhou University, Zhengzhou 450000, China.
Zigang DongPathophysiology Department, School of Basic Medical Sciences, Zhengzhou University, Zhengzhou 450000, China.
Kangdong LiuPathophysiology Department, School of Basic Medical Sciences, Zhengzhou University, Zhengzhou 450000, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Esophageal squamous cell carcinoma (ESCC), a malignancy of the digestive system, is highly prevalent and the primary cause of cancer-related deaths worldwide due to the lack of early diagnostic biomarkers and effective therapeutic targets. Dysregulated ribonucleotide reductase (RNR) expression has been confirmed to be causally linked to tumorigenesis. This study demonstrated that ribonucleotide reductase small subunit M2 (RRM2) is significantly upregulated in ESCC tissue and that its expression is negatively correlated with clinical outcomes. Mechanistically, HuR promotes

Indexed as

AU-rich elements (AREs)BifonazoleCell proliferationdNTPEsophageal squamous cell carcinoma (ESCC)Hu antigen R (HuR)mRNA stabilityRibonucleotide reductase small subunit M2 (RRM2)

Identifiers

PMID39525580
PMCPMC11544187

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.