Evidence map›Paper›PMID 39525504›Full record

ArticleFrontiers in nutrition2024

Interactions between the human milk oligosaccharide 2'-fucosyllactose and

Victoria C Daniels, Marcia H Monaco, Johanna Hirvonen, Arthur C Ouwehand, Henrik Max Jensen, Ratna Mukerjea, Niels Christensen, Markus J Lehtinen, Ryan N Dilger, Sharon M Donovan

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in nutrition, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. mSystems · 2026
    Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Victoria C DanielsDivision of Nutritional Sciences, University of Illinois, Urbana, IL, United States.
Marcia H MonacoDepartment of Food Science and Human Nutrition, University of Illinois, Urbana, IL, United States.
Johanna HirvonenIFF Health and Biosciences, Kantvik, Finland.
Arthur C OuwehandIFF Health and Biosciences, Kantvik, Finland.
Henrik Max JensenIFF R&D-Enabling Technologies, Brabrand, Denmark.
Ratna MukerjeaIFF Health and Biosciences, Saint Louis, MO, United States.
Niels ChristensenIFF R&D-Enabling Technologies, Brabrand, Denmark.
Markus J LehtinenIFF Health and Biosciences, Kantvik, Finland.
Ryan N DilgerDivision of Nutritional Sciences, University of Illinois, Urbana, IL, United States.
Sharon M DonovanDivision of Nutritional Sciences, University of Illinois, Urbana, IL, United States.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Introduction: The oligosaccharide 2'-fucosyllactose (2'-FL) is a predominant component of human milk, serving as a prebiotic for gut microbiota and influencing immune development in infants. Methods: Two-day-old piglets ( Results: Immune cell populations in PBMCs were unaffected by the experimental treatment. However, serum interleukin (IL)-1RA, IL-1β, IL-12, and IL-18 were all higher ( Conclusion: 2'-FL stimulates a balanced cytokine profile in healthy piglets without changing immune cell populations. When immune cells are stimulated

Indexed as

2-fucosyl-lactoseB. infantis Bi-26cytokinehuman milk oligosaccharidesimmune

Identifiers

PMID39525504
PMCPMC11543533

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.