ArticleCureus2024
Tonsillectomy Under the Microscope: Is Routine Histopathological Analysis Necessary?
Article in Cureus, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Introduction Tonsillectomy is the most common surgery in otorhinolaryngology worldwide, with many indications in adults and children. Traditionally, all tonsillectomy specimens are routinely submitted for histopathological examination, even in the absence of clinical suspicion of malignancy. This practice has been debated due to its resource implications and the low yield of malignancy in routine cases. In this study, we aim to determine the prevalence of occult malignancy in our population and assess the necessity of histopathology examination after routine tonsillectomies. Methodology This retrospective chart review was conducted on patients who underwent tonsillectomy between January 2018 and December 2019 at a single tertiary care center. The patients were divided into two groups: those undergoing routine tonsillectomy without clinical suspicion of malignancy and those with suspected malignancy based on preoperative evaluation. Results A total of 1857 tonsillectomy cases were analyzed, comprising 1839 routine cases with no suspicion of malignancy and 18 cases where malignancy was suspected. Among the routine cases, 1609 (87.5%) were pediatric patients, and 230 (12.5%) were adult patients. All cases in the suspected malignancy group were adults. In the routine tonsillectomy group, recurrent tonsillitis was the most common indication for surgery, observed in 821 (51.1%) pediatric patients and 160 (69.6%) adult patients. Reactive lymphoid hyperplasia was the most common histopathological finding, present in 1589 (98.8%) pediatric cases and 187 (81.3%) adult cases. No unexpected malignancies were identified in the routine tonsillectomy group (0%). In the suspected malignancy group, reactive lymphoid hyperplasia was identified in 13 cases (72.2%), lymphoma in four cases (22.2%), and squamous cell carcinoma (SCC) in one case (5.6%). All patients diagnosed with lymphoma presented with visible tonsillar lesions and palpable neck lymph nodes, three (75%) exhibited tonsillar asymmetry, and two (50%) reported weight loss. The single patient with SCC had asymmetrical tonsils, a visible tonsillar lesion, and palpable neck lymph nodes and experienced weight loss. Conclusion The study findings demonstrated no cases of unexpected malignancy in routine tonsillectomy specimens, reinforcing the argument that routine histopathological examination may not be necessary in the absence of clinical suspicion of malignancy. These results, along with considerations of cost-effectiveness and resource optimization, suggest that histopathological analysis may be reserved only for cases with clinical indicators of malignancy.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.