Evidence map›Paper›PMID 39525155›Full record

ArticleCureus2024

Associations Between Non-communicable Diseases and Obstetric Complications: A Retrospective Records Review at a Tertiary Referral Hospital in Uganda.

Leevan Tibaijuka, Joseph Ngonzi, Jean-Pierre Van Geertruyden, Asiphas Owaraganise, Lisa M Bebell, Musa Kayondo, Francis Bajunirwe, Yarine F Tornes, Yves Jacquemyn, Adeline A Boatin

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In one paragraph

Article in Cureus, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Leevan TibaijukaObstetrics and Gynecology, Mbarara University of Science and Technology, Mbarara, UGA.
Joseph NgonziObstetrics and Gynecology, Mbarara University of Science and Technology, Mbarara, UGA.
Jean-Pierre Van GeertruydenGlobal Health Institute, Department of Family Medicine and Population Health, Faculty of Medicine and Health Sciences, University of Antwerp, Antwerp, BEL.
Asiphas OwaraganiseClinical Division, Infectious Diseases Research Collaboration, Kampala, UGA.
Lisa M BebellMedicine, Massachusetts General Hospital, Harvard Medical School, Boston, USA.
Musa KayondoObstetrics and Gynecology, Mbarara University of Science and Technology, Mbarara, UGA.
Francis BajunirweCommunity Health, Mbarara University of Science and Technology, Mbarara, UGA.
Yarine F TornesObstetrics and Gynecology, Mbarara University of Science and Technology, Mbarara, UGA.
Yves JacquemynObstetrics and Gynecology, Antwerp University Hospital (UZA), Antwerp, BEL.
Adeline A BoatinObstetrics and Gynecology, Massachusetts General Hospital, Harvard Medical School, Boston, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveNon-communicable diseases (NCDs) increasingly contribute to maternal morbidity and mortality. We determined the association between NCDs and obstetric complications at Mbarara Regional Referral Hospital (MRRH) in southwestern Uganda.

methodsIn this retrospective records review, we randomly selected records of women admitted for delivery at MRRH each month from January to December 2022, and extracted their socio-demographic and clinical histories. We defined a history of NCDs as chronic hypertension, pre-gestational diabetes, cardiac disease, anemia, or asthma. We performed a multivariate robust Poisson regression analysis to assess the association between NCDs and obstetric complications, including preeclampsia, gestational diabetes, venous thromboembolic disease, obstetric hemorrhage, and preterm labor. Models were adjusted for maternal age, gravidity, referral status, employment status, and human immunodeficiency virus (HIV) serostatus.

resultsWe extracted data for 2,336 women with a mean age of 26±5.9 years. At least one NCD was present in 6.4% (n=149) of the patients, including anemia (n=77, 3.3%), chronic hypertension (n=35, 1.5%), pre-gestational diabetes (n=16, 0.7%), asthma (n=9, 0.4%), and cardiac disease (n=6, 0.3%). Overall, 542 (23.2%) women had obstetric complications, including preeclampsia (n=265, 11.3%), preterm labor (n=67, 2.9%), placental abruption (n=29, 1.2%), postpartum hemorrhage (PPH) (n=54, 2.3%), and gestational diabetes (n=5, 0.2%). Women with NCDs had an increased likelihood of having an obstetric complication compared to women without (overall proportion 33.6% vs 22.5% respectively); adjusted prevalence ratio (aPR) was 1.8 (95% CI: 1.4-2.3) overall, 1.8 (95%CI: 1.2-2.8) for preeclampsia, 12.0 (95%CI: 2.0-72.7) for gestational diabetes, 6.0 (95%CI: 1.3-27.1) for deep venous thrombosis, 4.4 (95%CI: 1.5-12.6) for placenta abruption, and 4.3 (95%CI: 2.2-8.3) for PPH.

conclusionsWe found that NCDs were associated with a nearly two-fold increase in the risk of obstetric complications. Our findings highlight the need for further research to understand the impact of this risk, particularly on maternal and fetal outcomes. Additionally, these findings suggest strengthened NCD surveillance, as a means of increasing preparedness, and management of potential obstetric complications among pregnant women in Uganda.

Indexed as

maternal healthmaternal morbiditynon-communicable diseasesobstetric complicationssub-saharan africa

Identifiers

PMID39525155
PMCPMC11548109

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.