ArticleTranslational cancer research2024
Up-regulation of MSMO1 was associated with poor survival in cervical cancer.
Article in Translational cancer research, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
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5 citing papers in PubMed.
- Transcriptomic Profiling of Canine Testicular Leydig Cell Tumors Uncovers Key Upregulated Gene Pathways.Animals : an open access journal from MDPI · 2026Article
- METTL16-mediated mJournal of experimental & clinical cancer research : CR · 2026Article
- Combined vitamins D3 and K2 as potential modulators of multiple myeloma cell pathophysiology: transcriptomic and epigenetic effects under standard culture and bone marrow-like conditions.Frontiers in oncology · 2026Article
- Tumour microbiota activities associated with local recurrence in ER + PR + breast cancer.Cancer biomarkers : section A of Disease markers · 2025Article
- Downregulation ofTranslational cancer research · 2025Article
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Abstract
Background: Methylsterol monooxygenase 1 (MSMO1) catalyzes C4-methylsterols demethylation in cholesterol biosynthesis pathway. MSMO1 is increased and up-regulation of MSMO1 is correlated with progression of some tumor. But the correlation of MSMO1 to cervical cancer is unknown. The current study aimed to explore the expression pattern of MSMO1 in cervical cancer and its correlation to clinical characteristics. Methods: In this study, 306 cervical cancer cases and 13 non-tumor cases were included. We compared MSMO1 expression level in non-tumor cervical tissues and cervical cancer samples using the Wilcoxon rank sum test. Univariate regression was used to investigate the correlation between MSMO1 expression as well as other clinical characteristics and prognosis. Clinical characteristics associated with prognosis in univariate analysis were used as adjustments for multivariate analysis to further validate the relationship between MSMO1 expression and cervical cancer prognosis. Patients' survival in different subgroups was compared by Kaplan-Meier (KM) method. The potential protein interaction was analyzed. T cell infiltration level in MSMO1 high and low group patients was compared. Results: MSMO1 expression level was up-regulated in cervical cancer (P<0.001). Patients who had stage III-IV diseases (P=0.04) and did not achieve complete response after primary treatment had higher MSMO1 expression (P<0.001). High MSMO1 expression patients showed a lower overall survival (OS) (P=0.004), disease-specific survival (DSS) (P=0.004) and progression-free survival (PFS) (P=0.002). High MSMO1 expression was a risk factor to OS (P=0.01), DSS (P=0.009) and PFS (P=0.009). Multiple variate analysis showed that high MSMO1 expression was an independent risk factor to OS [hazard ratio (HR) =1.902, 95% confidence interval (CI): 1.156-3.129, P=0.01], DSS (HR =2.172, 95% CI: 1.210-3.897, P=0.009) and PFS (HR =1.975, 95% CI: 1.189-3.282, P=0.009) in cervical squamous cell carcinoma (CESC). The prognostic value of high MSMO1 expression was further examined in other databases, including KM-plotter, Gene Expression Profiling Interactive Analysis (GEPIA) and Gene Expression Omnibus (GEO) database. Conclusions: The current research showed that MSMO1 was increased and was associated with poor prognosis in CESC.
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