Evidence map›Paper›PMID 39524935›Full record

ArticleNeurobiology of stress2024

Dopamine and D1 receptor in hippocampal dentate gyrus involved in chronic stress-induced alteration of spatial learning and memory in rats.

Linping Wang, Weiyao Wang, Yingshun Li, Hua Jin, Bin Xiao, Qinghua Jin

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Neurobiology of stress, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Deletion ofFrontiers in cellular neuroscience · 2026
    Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Linping WangKey Laboratory of Cellular Function and Pharmacology of Jilin Province, Yanbian University, Yanji, China.
Weiyao WangDepartment of Physiology, College of Basic Medicine, Jilin Medical University, Jilin, China.
Yingshun LiKey Laboratory of Cellular Function and Pharmacology of Jilin Province, Yanbian University, Yanji, China.
Hua JinDepartment of Internal Medicine, Yanbian University Hospital, Yanji, China.
Bin XiaoKey Laboratory of Cellular Function and Pharmacology of Jilin Province, Yanbian University, Yanji, China.
Qinghua JinKey Laboratory of Cellular Function and Pharmacology of Jilin Province, Yanbian University, Yanji, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

There is increasing evidence that chronic stress (CS), which occurs when the body is exposed to prolonged stressors, significantly impairs learning and memory. Dopamine (DA) plays a critical role in learning and memory in the hippocampus through the activation of D1-like receptors (D1R). However, the specific roles of DA and D1R in the hippocampal dentate gyrus (DG), particularly in CS-induced changes in spatial learning and memory, are not well understood. In this study, we established a CS rat model through the random application of various stressors. We assessed spatial learning and memory using the Morris water maze (MWM) and measured DA concentration and the amplitude of field excitatory postsynaptic potentials (fEPSP) in the DG during the MWM test in freely moving rats. We also examined the involvement of D1R in spatial learning and memory by microinjecting its antagonist (SCH23390) into the DG, and then analyzed the expressions of phosphorylated (p-) Ca

Indexed as

Chronic stressD1 receptorDopamineHippocampal dentate gyrusLearning and memoryRats

Identifiers

PMID39524935
PMCPMC11550135

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.