ReviewHeliyon2024
A comprehensive review of capsaicin: Biosynthesis, industrial productions, processing to applications, and clinical uses.
Review in Heliyon, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
20 citing papers in PubMed.
- Dynamic changes in volatile flavor compounds and capsaicinoids and their interrelationships in eight chili pepper cultivars across three ripening stages.Food chemistry: X · 2026Article
- Lighting up the pepper heat.The New phytologist · 2026Article
- Capsaicin Induces G2/M Cell-Cycle Arrest and Impairs Autophagy in Caco-2 Cells: An Exploratory Study.International journal of molecular sciences · 2026Article
- Organ-on-a-Chip and Microfluidic Plant Cell Culture Systems: The Next Frontier for Controlled Secondary Metabolite Production and Real-Time Metabolomic Monitoring.Plants (Basel, Switzerland) · 2026Review
- Article
- Capsaicin inhibits cariogenicJournal of oral microbiology · 2026Article
- Spicy genes: mapping quantitative genomic regions and candidate genes for capsaicinoid and capsinoid biosynthesis in pepper.Frontiers in plant science · 2026Review
- Synergistic role of plant growth-promoting rhizobacteria and fungi in biofertilizer development for chilli (Frontiers in plant science · 2026Review
- Heterosis and combining ability analysis of Phytophthora capsici induced root rot resistance and horticultural traits in Capsicum annuum.Scientific reports · 2025Article
- Effect of Crosslinking Using Heat on the Physicochemical Features of Bsa-Capsaicin Nanoparticles.Pharmaceutics · 2025Article
- Unlocking the Alkaloid Biological Potential of Chili Pepper (Molecules (Basel, Switzerland) · 2025Review
- Protective effect of capsaicin on AKT1 and MAPK1 expression in the liver of mice (Open veterinary journal · 2025Article
- Immunomodulatory Effects of Traditional Korean Gochujang in Rats Immunosuppressed with Cyclophosphamide.International journal of molecular sciences · 2025Article
- Prohexadione calcium and KHBMC plant biology · 2025Article
- Capsaicin as a Microbiome Modulator: Metabolic Interactions and Implications for Host Health.Metabolites · 2025Review
- Synthesis, physicochemical characterization and biological activity of novel pyrrole flavones.Scientific reports · 2025Article
- Indole-2-Carboxamide as an Effective Scaffold for the Design of New TRPV1 Agonists.Molecules (Basel, Switzerland) · 2025Article
- Dietary polyphenols and human health: sources, biological activities, nutritional and immunological aspects, and bioavailability- a comprehensive review.Frontiers in immunology · 2025Review
- Exploring capsaicin as a multi-target agent for osteoporosis through computational insights.In silico pharmacology · 2025Article
- Bioactivity assessment of methanolic extract ofJournal of advanced pharmaceutical technology & researchArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Capsaicin, the main bioactive compound in chili peppers, is widely known for its diverse pharmacological effects, including antioxidant, anti-inflammatory, and anticancer effects. Despite its therapeutic potential, the low yield of natural capsaicin and the challenges in producing it on a large-scale limit broader industrial and clinical applications. This review provides a comprehensive analysis of capsaicin's biosynthesis in plants, chemical and enzymatic synthesis methods, and recent advancements in green production technologies. In addition, innovative applications such as drug delivery systems using nanoencapsulation and micelles are being developed to improve the bioavailability and therapeutic efficacy of capsaicin. Key findings highlight the use of capsaicin in food preservation, packaging, and pharmaceutical formulations. Future research should prioritize the refinement of synthetic routes, innovative delivery technologies, and the development of sustainable industrial processes to fully exploit the therapeutic and commercial potential of capsaicin.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.