Evidence map›Paper›PMID 39524681›Full record

ArticleACS omega2024

Gold Nanoparticles for Photothermal and Photodynamic Therapy.

Matthew Broadbent, Samantha J Chadwick, Mathias Brust, Martin Volk

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in ACS omega, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed.

  1. Article
  2. Review
  3. Review
  4. Review
  5. Review
  6. Article
  7. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Matthew BroadbentDepartment of Chemistry, University of Liverpool, Crown Street, Liverpool L69 7ZD, U.K.
Samantha J ChadwickDepartment of Chemistry, University of Liverpool, Crown Street, Liverpool L69 7ZD, U.K.
Mathias BrustDepartment of Chemistry, University of Liverpool, Crown Street, Liverpool L69 7ZD, U.K.ORCID https://orcid.org/0000-0001-6301-7123
Martin VolkDepartment of Chemistry, University of Liverpool, Crown Street, Liverpool L69 7ZD, U.K.ORCID https://orcid.org/0000-0003-3555-8584

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Cancer cells exposed to 13 nm gold nanoparticles and irradiated with cw laser light at 532 nm are shown to undergo cell death via two competing causes. When cells contain relatively high quantities of gold nanoparticles and/or receive a high dose of light, photothermal effects dominate, which are independent of the cellular location of the gold nanoparticles and affect all cells in the irradiated area due to the rapid diffusion of heat. In contrast, at lower doses of nanoparticles and light, the photogeneration of singlet oxygen triggers cell death only in cells that contain a sufficient number of nanoparticles. The parallel occurrence of both effects will need to be considered carefully when designing practical therapy applications. In particular, the photodynamic effect should allow for a cell-type-specific treatment modality that can distinguish between cancer and normal cells using suitable targeting ligands on the nanoparticle surface, providing a highly selective route for cancer therapy.

Identifiers

PMID39524681
PMCPMC11541516

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.