Evidence map›Paper›PMID 39524642›Full record

ArticleACS omega2024

Synthesis of Tryptamine-Thiazolidin-4-one Derivatives and the Combined

Seher Aydın, Yavuz Ergün, Salma Ghazy, Asuman Çelebi, Turker Kilic, Timuçin Avşar, Serdar Durdağı

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in ACS omega, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Seher AydınDokuz Eylul University, The Graduate School of Natural and Applied Sciences, Kaynaklar Campus, Buca, Izmir 35160, Türkiye.
Yavuz ErgünDokuz Eylul University, Faculty of Sciences, Department of Chemistry, Kaynaklar Campus, Buca, Izmir 35160, Türkiye.
Salma GhazyComputational Biology and Molecular Simulations Laboratory, Department of Biophysics, School of Medicine, Bahçeşehir University, Istanbul 34353, Türkiye.
Asuman ÇelebiDepartment of Medical Biology, School of Medicine, Bahcesehir University, Istanbul 34353, Türkiye.
Turker KilicDepartment of Neurosurgery, School of Medicine, Bahcesehir University, Istanbul 34353, Türkiye.
Timuçin AvşarDepartment of Medical Biology, School of Medicine, Bahcesehir University, Istanbul 34353, Türkiye.
Serdar DurdağıComputational Biology and Molecular Simulations Laboratory, Department of Biophysics, School of Medicine, Bahçeşehir University, Istanbul 34353, Türkiye.ORCID https://orcid.org/0000-0002-0426-0905

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Tryptamine, a monoamine alkaloid with an indole ring structure, is derived from the decarboxylation of the amino acid tryptophan, which is present in fungi, plants, and animals. Tryptamine analogues hold significant therapeutic potential due to their broad pharmacological activities, including roles as neurotransmitters and potential therapeutic agents for various diseases. Structural modifications of tryptamine enhance receptor selectivity and metabolic stability, improving therapeutic efficacy. These modifications are crucial for optimizing pharmacokinetic and pharmacodynamic properties, making the analogues more effective and safer for clinical use. In this study, novel tryptamine-thiazolidin-4-one (

Identifiers

PMID39524642
PMCPMC11541526

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.