Evidence map›Paper›PMID 39524621›Full record

ArticleACS omega2024

Toward New Therapeutics for Visceral Leishmaniasis: Efficacy and Mechanism of Action of Amides Inspired by Gibbilimbol B.

Fabio Navarro Baltazar, Maiara Amaral, Maiara Maria Romanelli, Erica Valadares de Castro Levatti, Fernanda Fonseca Ramos, Luiz Paulo Melchior de Oliveira Leão, Daniela Aparecida Chagas-Paula, Marisi Gomes Soares, Danielle Ferreira Dias, Cecilia M S Q Aranha and 3 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in ACS omega, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Fabio Navarro BaltazarPathophysiology Laboratory, Instituto Butantan, Av. Vital Brazil, 1500, 05503-900 São Paulo, São Paulo, Brazil.
Maiara AmaralPathophysiology Laboratory, Instituto Butantan, Av. Vital Brazil, 1500, 05503-900 São Paulo, São Paulo, Brazil.
Maiara Maria RomanelliPathophysiology Laboratory, Instituto Butantan, Av. Vital Brazil, 1500, 05503-900 São Paulo, São Paulo, Brazil.
Erica Valadares de Castro LevattiPathophysiology Laboratory, Instituto Butantan, Av. Vital Brazil, 1500, 05503-900 São Paulo, São Paulo, Brazil.
Fernanda Fonseca RamosPathophysiology Laboratory, Instituto Butantan, Av. Vital Brazil, 1500, 05503-900 São Paulo, São Paulo, Brazil.ORCID https://orcid.org/0000-0002-7852-0300
Luiz Paulo Melchior de Oliveira LeãoInstitute of Chemistry, Federal University of Alfenas (UNIFAL), R. Gabriel Monteiro da Silva, 700, 37130-000 Alfenas, Minas Gerais, Brazil.
Daniela Aparecida Chagas-PaulaInstitute of Chemistry, Federal University of Alfenas (UNIFAL), R. Gabriel Monteiro da Silva, 700, 37130-000 Alfenas, Minas Gerais, Brazil.ORCID https://orcid.org/0000-0003-2274-4919
Marisi Gomes SoaresInstitute of Chemistry, Federal University of Alfenas (UNIFAL), R. Gabriel Monteiro da Silva, 700, 37130-000 Alfenas, Minas Gerais, Brazil.
Danielle Ferreira DiasInstitute of Chemistry, Federal University of Alfenas (UNIFAL), R. Gabriel Monteiro da Silva, 700, 37130-000 Alfenas, Minas Gerais, Brazil.ORCID https://orcid.org/0000-0001-9129-4734
Cecilia M S Q AranhaDepartment of Medicine, Federal University of São Paulo (UNIFESP), Av. Dr. Arnaldo, 455, 01246-903 São Paulo, São Paulo, Brazil.
João Paulo Dos Santos FernandesDepartment of Pharmaceutical Sciences, Federal University of São Paulo, Rua São Nicolau, 210, 09913030 Diadema, São Paulo, Brazil.ORCID https://orcid.org/0000-0002-9089-273X
Joao Henrique Ghilardi LagoCentre of Natural Sciences and Humanities, Universidade Federal do ABC, Av. dos Estados, 5001, 09210-580 Santo André, São Paulo, Brazil.ORCID https://orcid.org/0000-0002-1193-8374
Andre Gustavo TemponePathophysiology Laboratory, Instituto Butantan, Av. Vital Brazil, 1500, 05503-900 São Paulo, São Paulo, Brazil.ORCID https://orcid.org/0000-0003-2559-7344

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The problems with current strategies to control canine visceral Leishmaniasis (CVL), which include the euthanasia of infected animals, and also the toxicity of the drugs currently used in human treatments for CVL, add urgency to the search for new therapeutic agents. This study aimed to evaluate the activity against

Identifiers

PMID39524621
PMCPMC11541474

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.