ArticleACS omega2024
Preparation of Paeonol Ethosomes by Microfluidic Technology Combined with Gaussians and Evaluation of Biological Activity by Zebrafish.
Article in ACS omega, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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Who cites it
3 citing papers in PubMed.
- Study of the Stability and Anti-Inflammatory Activity of Paeonol-Oleanolic Acid Liposomes by Microfluidic Technology.Foods (Basel, Switzerland) · 2025Article
- Modified Phospholipid Vesicular Gel for Transdermal Drug Delivery: The Influence of Glycerin and/or Ethanol on Their Lipid Bilayer Fluidity and Penetration Characteristics.Gels (Basel, Switzerland) · 2025Review
- Development and Characterization of a Hydrogel Containing Chloramphenicol-Loaded Binary Ethosomes for Effective Transdermal Permeation and Treatment Acne in Rat Model.International journal of nanomedicine · 2025Article
Corrections and comments
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Authors and funding
10 authors.
Funding
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Abstract
Paeonol, a monoterpene glycoside compound, has extensive pharmacological activities. However, its applications are restricted by poor water solubility and low bioavailability. In this study, paeonol ethosomes (PAE-ethosomes) were successfully prepared with a microfluidic method by optimizing the single factors and RSM test. The enhanced PAE-ethosomes were assessed using transmission electron microscopy (TEM), Fourier transform infrared spectroscopy (FT-IR), vesicle size (VS), zeta potential (ZP), and polydispersity index (PDI). Density functional theory analysis was employed to verify the molecular interaction. The optimized RSM conditions were a phospholipid concentration of 6 mg/mL, a cholesterol concentration of 1 mg/mL, and a total flow rate of 600 μL/min with a presumed value of 60.3% and confirmation results of 61.2 ± 0.3%. The prepared PAE-ethosomes showed better storage stability and a slow-release effect. The
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Registered trials
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