Evidence map›Paper›PMID 39524606›Full record

ArticleFrontiers in physiology2024

Muscle-restricted knockout of connexin 43 and connexin 45 accelerates and improves locomotor recovery after contusion spinal cord injury.

Carlos A Toro, Rita De Gasperi, Katherine Vanselow, Lauren Harlow, Kaitlin Johnson, Abdurrahman Aslan, William A Bauman, Christopher P Cardozo, Zachary A Graham

Erratum issuedAbstract read
In one paragraph

Article in Frontiers in physiology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 2 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

9 authors.

Carlos A ToroSpinal Cord Damage Research Center, Bronx, NY, United States.
Rita De GasperiSpinal Cord Damage Research Center, Bronx, NY, United States.
Katherine VanselowHealthspan, Resilience and Performance, Florida Institute for Human and Machine Cognition, Pensacola, FL, United States.
Lauren HarlowSpinal Cord Damage Research Center, Bronx, NY, United States.
Kaitlin JohnsonSpinal Cord Damage Research Center, Bronx, NY, United States.
Abdurrahman AslanSpinal Cord Damage Research Center, Bronx, NY, United States.
William A BaumanSpinal Cord Damage Research Center, Bronx, NY, United States.
Christopher P CardozoSpinal Cord Damage Research Center, Bronx, NY, United States.
Zachary A GrahamHealthspan, Resilience and Performance, Florida Institute for Human and Machine Cognition, Pensacola, FL, United States.

Funding

National Center on Medical Consequences of Spinal Cord InjuryI50RX002020 · VA · JAMES J PETERS VA MEDICAL CENTER · PI BAUMAN, WILLIAM A, SPUNGEN, ANN MICHELE · 2016 to 2020
–
Mechanisms and treatments of mitochondrial dysfunction in paralyzed skeletal muscle after spinal cord injuryIK2RX002781 · VA · JAMES J PETERS VA MEDICAL CENTER · PI GRAHAM, ZACHARY AARON · 2018 to 2024
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RRD VA I50 RX002020RRD VA IK2 RX002781
6 · The paper itself

Abstract

Traumatic spinal cord injury (SCI) results in the disruption of physiological systems below the level of the spinal lesion. Connexin hemichannels (CxHCs) are membrane-bound, non-selective pore proteins that are lost in mature myofibers but reappear

Indexed as

contusion spinal cord injuryCx43Cx45recovery of functionskeletal muscle-restricted knockoutspinal cord injurytransection spinal cord injury

Identifiers

PMID39524606
PMCPMC11543431

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.