Evidence map›Paper›PMID 39524371›Full record

ArticleJournal of heterocyclic chemistry2024

Structure-Activity Relationship Investigations Probing the Cytotoxicity of 9-Aminoacridines Derivatives with PC3 and A549.

Grace S Blount, Austin Seymour, Dylan Williams, Daylon Douglas, Joshua Miller, Sarah Sejoro, Karl Peace, R Jannet Kocerha, Karelle S Aiken

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of heterocyclic chemistry, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Grace S BlountBiochemistry, Chemistry and Physics Department, Georgia Southern University, PO Box 8064, Statesboro, GA 30460.
Austin SeymourBiochemistry, Chemistry and Physics Department, Georgia Southern University, PO Box 8064, Statesboro, GA 30460.
Dylan WilliamsBiochemistry, Chemistry and Physics Department, Georgia Southern University, PO Box 8064, Statesboro, GA 30460.
Daylon DouglasBiochemistry, Chemistry and Physics Department, Georgia Southern University, PO Box 8064, Statesboro, GA 30460.
Joshua MillerBiochemistry, Chemistry and Physics Department, Georgia Southern University, PO Box 8064, Statesboro, GA 30460.
Sarah SejoroDepartment of Biostatistics, Epidemiology, & Environmental Health Sciences, Jiann-Ping Hsu College of Public Health, Georgia Southern University, Statesboro, GA 30460.
Karl PeaceJiann-Ping Hsu College of Public Health, Georgia Southern University, Sr. Research Scientist, Professor of Biostatistics, Georgia Cancer Coalition Cancer Professor, FASA, Statesboro, GA 30460.
R Jannet KocerhaBiochemistry, Chemistry and Physics Department, Georgia Southern University, PO Box 8064, Statesboro, GA 30460.
Karelle S AikenBiochemistry, Chemistry and Physics Department, Georgia Southern University, PO Box 8064, Statesboro, GA 30460.

Funding

The Design and Study of Anticancer Therapeutics Inspired by Natural Substrates of LAT1R15CA277652 · NCI · GEORGIA SOUTHERN UNIVERSITY · PI AIKEN, KARELLE, KOCERHA, REBECCA JANNET · 2023 to 2023
$425k
NCI NIH HHS R15 CA277652
6 · The paper itself

Abstract

9-Aminoacridine structures hold much potential for accessing small molecule therapeutics. This core is present in a range of pharmaceuticals for the treatment of ailments such as malaria, inflammation, viral and bacterial infections, and cancer. For the latter, there remains a need to develop and/or improve chemotherapeutics to counteract issues of uptake, drug resistance, and selectivity for cancer cells over healthy cells. In the design of molecules to address these issues, identifying structural units that present as promising leads for drug developments is key. In this study, four 9-aminoacridine derivatives under consideration as precursors for a drug design project are assessed for their cytotoxicity with representative cell lines PC3 and A549, and for their leadlikeness with SwissADME. Together, the cytotoxicity and

Indexed as

9-aminoacridinecancerchemotherapeuticleadlikenessstructure-activity relationship

Identifiers

PMID39524371
PMCPMC11548829

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.