Evidence map›Paper›PMID 39524368›Full record

ArticleiScience2024

High glycemic variability is associated with a reduced T cell cytokine response to influenza A virus.

Marcus Z W Tong, Katina D Hulme, Soi Cheng Law, Ellesandra Noye, Emily S Dorey, Keng Yih Chew, Louise C Rowntree, Carolien E van de Sandt, Katherine Kedzierska, Marco Goeijenbier and 11 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in iScience, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

21 authors.

Marcus Z W TongSchool of Chemistry and Molecular Biosciences, The University of Queensland, St Lucia, QLD, Australia.
Katina D HulmeSchool of Chemistry and Molecular Biosciences, The University of Queensland, St Lucia, QLD, Australia.
Soi Cheng LawMater Research Institute, The University of Queensland, Translational Research Institute, Brisbane, QLD, Australia.
Ellesandra NoyeSchool of Chemistry and Molecular Biosciences, The University of Queensland, St Lucia, QLD, Australia.
Emily S DoreyMater Research Institute, The University of Queensland, Translational Research Institute, Brisbane, QLD, Australia.
Keng Yih ChewSchool of Chemistry and Molecular Biosciences, The University of Queensland, St Lucia, QLD, Australia.
Louise C RowntreeDepartment of Microbiology and Immunology, University of Melbourne, at the Peter Doherty Institute for Infection and Immunity, Melbourne, VIC, Australia.
Carolien E van de SandtDepartment of Microbiology and Immunology, University of Melbourne, at the Peter Doherty Institute for Infection and Immunity, Melbourne, VIC, Australia.
Katherine KedzierskaDepartment of Microbiology and Immunology, University of Melbourne, at the Peter Doherty Institute for Infection and Immunity, Melbourne, VIC, Australia.
Marco GoeijenbierDepartment of Intensive Care, Erasmus MC, Rotterdam, the Netherlands.
Katharina RonacherMater Research Institute, The University of Queensland, Translational Research Institute, Brisbane, QLD, Australia.
Fawaz AlzaidUniversité Paris Cité, CNRS, INSERM, Institut Necker Enfants Malades-INEM, F-75015 Paris, France.
Jean-Baptiste JullaUniversité Paris Cité, CNRS, INSERM, Institut Necker Enfants Malades-INEM, F-75015 Paris, France.
Jean-Pierre RivelineUniversité Paris Cité, CNRS, INSERM, Institut Necker Enfants Malades-INEM, F-75015 Paris, France.
Katie E LineburgQIMR Berghofer Medical Research Institute, Brisbane, QLD, Australia.
Corey SmithQIMR Berghofer Medical Research Institute, Brisbane, QLD, Australia.
Emma J GrantDepartment of Biochemistry and Chemistry, La Trobe Institute for Molecular Science, Bundoora, VIC, Australia.
Stephanie GrasDepartment of Biochemistry and Chemistry, La Trobe Institute for Molecular Science, Bundoora, VIC, Australia.
Linda A GalloSchool of Health and Behavioural Sciences, University of the Sunshine Coast, Petrie, QLD, Australia.
Helen L BarrettMater Research Institute, The University of Queensland, Translational Research Institute, Brisbane, QLD, Australia.
Kirsty R ShortSchool of Chemistry and Molecular Biosciences, The University of Queensland, St Lucia, QLD, Australia.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Diabetes mellitus significantly increases the risk of severe respiratory virus disease like influenza and COVID-19. Early evidence suggests that this susceptibility to respiratory viral disease is driven by glycemic variability, rather than average blood glucose levels. Here, we use blood samples and constant glucose monitoring (CGM) data obtained from people living with type 1 diabetes (T1D) to determine the effects of glycemic variability on the

Indexed as

EndocrinologyHuman metabolism

Identifiers

PMID39524368
PMCPMC11550119

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.