Evidence map›Paper›PMID 39524327›Full record

ArticleiScience2024

Core circadian transcription factor Bmal1 mediates β cell response and recovery from pro-inflammatory injury.

Kuntol Rakshit, Matthew R Brown, Naureen Javeed, Jeong-Heon Lee, Tamas Ordog, Aleksey V Matveyenko

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in iScience, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Research Progress of BMAL1 in Heart Failure.Journal of the American Heart Association · 2025
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Kuntol RakshitDepartment of Physiology and Biomedical Engineering, Mayo Clinic School of Medicine, Rochester, MN, USA.
Matthew R BrownDepartment of Physiology and Biomedical Engineering, Mayo Clinic School of Medicine, Rochester, MN, USA.
Naureen JaveedDepartment of Physiology and Biomedical Engineering, Mayo Clinic School of Medicine, Rochester, MN, USA.
Jeong-Heon LeeEpigenomics Program, Center for Individualized Medicine, Mayo Clinic, Rochester, MN, USA.
Tamas OrdogDepartment of Physiology and Biomedical Engineering, Mayo Clinic School of Medicine, Rochester, MN, USA.
Aleksey V MatveyenkoDepartment of Physiology and Biomedical Engineering, Mayo Clinic School of Medicine, Rochester, MN, USA.

Funding

Role of Circadian Misalignment in Beta-cell Failure in Type 2 DiabetesR01DK098468 · NIDDK · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI ALEKSEY V MATVEYENKO · 2013 to 2026
$5.8M
NIDDK NIH HHS R01 DK098468
6 · The paper itself

Abstract

The circadian clock plays a vital role in modulating the cellular immune response. However, its role in mediating pro-inflammatory diabetogenic β cell injury remains largely unexplored. Our studies demonstrate that the exposure of β cells to IL-1β-mediated inflammation alters genome-wide DNA binding of core circadian transcription factors BMAL1:CLOCK enriched for genomic sites important for cellular response to inflammation. Correspondingly, conditional deletion of

Indexed as

Cell biologyImmunologyMolecular biology

Identifiers

PMID39524327
PMCPMC11550590

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.