Evidence map›Paper›PMID 39524225›Full record

ArticleFrontiers in cell and developmental biology2024

Protamine 2 deficiency results in Septin 12 abnormalities.

Ondrej Sanovec, Michaela Frolikova, Veronika Kraus, Jana Vondrakova, Maryam Qasemi, Daniela Spevakova, Ondrej Simonik, Lindsay Moritz, Drew Lewis Caswell, Frantisek Liska and 8 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in cell and developmental biology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Protamine lacunae preserve the paternal chromatin landscape in sperm.bioRxiv : the preprint server for biology · 2025
    Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

18 authors.

Ondrej Sanovec *Laboratory of Reproductive Biology, Institute of Biotechnology, Czech Academy of Sciences, BIOCEV, Vestec, Czechia.
Michaela Frolikova *Laboratory of Reproductive Biology, Institute of Biotechnology, Czech Academy of Sciences, BIOCEV, Vestec, Czechia.
Veronika KrausLaboratory of Reproductive Biology, Institute of Biotechnology, Czech Academy of Sciences, BIOCEV, Vestec, Czechia.
Jana VondrakovaLaboratory of Reproductive Biology, Institute of Biotechnology, Czech Academy of Sciences, BIOCEV, Vestec, Czechia.
Maryam QasemiLaboratory of Reproductive Biology, Institute of Biotechnology, Czech Academy of Sciences, BIOCEV, Vestec, Czechia.
Daniela SpevakovaLaboratory of Reproductive Biology, Institute of Biotechnology, Czech Academy of Sciences, BIOCEV, Vestec, Czechia.
Ondrej SimonikLaboratory of Reproductive Biology, Institute of Biotechnology, Czech Academy of Sciences, BIOCEV, Vestec, Czechia.
Lindsay MoritzDepartment of Human Genetics, University of Michigan, Ann Arbor, MI, United States.
Drew Lewis CaswellDepartment of Biological Sciences, College of Natural Sciences and Mathematics, University of Toledo, Toledo, OH, United States.
Frantisek LiskaInstitute of Biology and Medical Genetics, First Faculty of Medicine, Charles University and General University Hospital in Prague, Prague, Czechia.
Lukas DedLaboratory of Reproductive Biology, Institute of Biotechnology, Czech Academy of Sciences, BIOCEV, Vestec, Czechia.
Jiri CernyLaboratory of Structural Bioinformatics of Proteins, Institute of Biotechnology Czech Academy of Sciences, BIOCEV, Vestec, Czechia.
Tomer Avidor-ReissDepartment of Biological Sciences, College of Natural Sciences and Mathematics, University of Toledo, Toledo, OH, United States.
Saher Sue HammoudDepartment of Human Genetics, University of Michigan, Ann Arbor, MI, United States.
Hubert SchorleDepartment of Developmental Pathology, Institute of Pathology, University Hospital Bonn, Bonn, Germany.
Pavla PostlerovaLaboratory of Reproductive Biology, Institute of Biotechnology, Czech Academy of Sciences, BIOCEV, Vestec, Czechia.
Klaus StegerClinic of Urology, Paediatric Urology and Andrology, Molecular Andrology, Justus Liebig University of Giessen, Giessen, Germany.
Katerina KomrskovaLaboratory of Reproductive Biology, Institute of Biotechnology, Czech Academy of Sciences, BIOCEV, Vestec, Czechia.

Funding

The Role of Rabbit POC1B inSperm CentriolesR15HD110863 · NICHD · UNIVERSITY OF TOLEDO · PI AVIDOR-REISS, TOMER · 2023 to 2023
$452k
NICHD NIH HHS R15 HD110863
6 · The paper itself

Abstract

There is a well-established link between abnormal sperm chromatin states and poor motility, however, how these two processes are interdependent is unknown. Here, we identified a possible mechanistic insight by showing that Protamine 2, a nuclear DNA packaging protein in sperm, directly interacts with cytoskeletal protein Septin 12, which is associated with sperm motility. Septin 12 has several isoforms, and we show, that in the

Indexed as

annulusasthenozoospermiaProtamine 2 deficiencySeptin 12spermsperm immotility

Identifiers

PMID39524225
PMCPMC11543461

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.