Evidence map›Paper›PMID 39524221›Full record

ArticleADMET & DMPK2024

Michele D Spampinato, Anna Costanzini, Roberto De Giorgio, Angelina Passaro, Nicola Realdon, Fabrizio Bortolotti, Sabrina Banella, Gaia Colombo

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in ADMET & DMPK, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Michele D SpampinatoDepartment of Translational Medicine, St. Anna University Hospital, University of Ferrara, 44124 Ferrara, Italy.
Anna CostanziniDepartment of Translational Medicine, St. Anna University Hospital, University of Ferrara, 44124 Ferrara, Italy.
Roberto De GiorgioDepartment of Translational Medicine, St. Anna University Hospital, University of Ferrara, 44124 Ferrara, Italy.
Angelina PassaroDepartment of Translational Medicine, St. Anna University Hospital, University of Ferrara, 44124 Ferrara, Italy.
Nicola RealdonDepartment of Pharmaceutical and Pharmacological Sciences, University of Padova, 35131 Padova, Italy.
Fabrizio BortolottiDepartment of Life Sciences and Biotechnology, University of Ferrara, Via Fossato di Mortara 19, 44121 Ferrara, Italy.
Sabrina BanellaDepartment of Life Sciences and Biotechnology, University of Ferrara, Via Fossato di Mortara 19, 44121 Ferrara, Italy.
Gaia ColomboDepartment of Life Sciences and Biotechnology, University of Ferrara, Via Fossato di Mortara 19, 44121 Ferrara, Italy.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background and Purpose: Aiming to achieve light sedation via intranasal administration, this study showed that propofol (PPF) did not permeate across the rabbit nasal mucosa ex vivo from its marketed emulsion for injection. Experimental approach: Dilution of the emulsion with methyl-β-cyclodextrin in saline solution increased propofol solubility in water and diffusion across the nasal epithelium. Key results and conclusion: Despite these positive effects of the cyclodextrin, the amount of PPF permeated was minimal in 3 h, exceeding the formulation residence time in the nose. These results highlight the key role of formulation and the need for innovation in solubility and transmucosal transport enhancement techniques to optimize drug delivery and therapeutic efficacy.

Indexed as

aqueous solubilitynasal administrationn-cyclodextrinSedative drugtransmucosal permeation

Identifiers

PMID39524221
PMCPMC11542715

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.