Evidence map›Paper›PMID 39524158›Full record

ArticleCureus2024

Restoring Function in Pediatric Neurodegeneration: The Impact of Radio Electric Asymmetric Conveyor Neuroregenerative Treatment in a Child With Canavan Syndrome.

Vania Fontani, Arianna Rinaldi, Salvatore Rinaldi

Abstract readCase Reports
In one paragraph

Article in Cureus, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Vania FontaniDepartment of Research, Rinaldi Fontani Foundation, Florence, ITA.
Arianna RinaldiDepartment of Regenerative Medicine, Rinaldi Fontani Institute, Florence, ITA.
Salvatore RinaldiDepartment of Research, Rinaldi Fontani Foundation, Florence, ITA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

This case report presents the therapeutic impact of radio electric asymmetric conveyor (REAC) neuroregenerative medicine treatment (REAC RGN-N) in a 10-year-old girl diagnosed with Canavan syndrome, a rare genetic disorder marked by progressive white matter degeneration in the brain. This condition, caused by aspartoacylase deficiency, leads to an accumulation of N-acetyl-L-aspartic acid (NAA), resulting in severe motor impairment, muscle tone abnormalities, and developmental delays. The patient received REAC RGN-N treatment, administered via the REAC - BENE mod 110 (ASMED®, Scandicci, Italy), specifically configured for RGN-N therapy. The protocol consisted of four 6-hour sessions completed over a 24-hour cycle. Following this initial treatment, the patient showed notable improvements in head and trunk control, muscle tone, and swallowing function. Head and trunk control increased from 20 to 30 on the trunk control measurement scale (TCMS), spasticity decreased from a score of 3 to 1 on the Ashworth scale, and her swallowing ability progressed from level 5 to level 7 on the functional oral intake scale (FOIS), allowing her to handle a wider range of food textures independently. These improvements were assessed six months after the end of the first treatment cycle, suggesting a degree of stability in the therapeutic effects observed. Although further studies could support these findings, the rarity of Canavan syndrome presents challenges for conducting additional targeted research. REAC RGN-N treatment is typically repeated in cycles every 4-6 months, depending on clinical severity, to sustain therapeutic benefits. This case report offers initial evidence that REAC RGN-N may provide meaningful, stable improvements for pediatric patients with neurodegenerative conditions, addressing motor and sensory impairments with potential long-term benefits.

Indexed as

canvascellular bioelectrical modulationfunctional oral intake scale (fois)motor function recoveryneuroregenerative medicinepediatric neurodegenerationpostural controlreac technologyspasticity reductiontrunk control measurement scale (tcms)

Identifiers

PMID39524158
PMCPMC11549842

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.