Evidence map›Paper›PMID 39523913›Full record

ArticleJournal of surgical oncology2025

Intraoperative Peripheral Frozen Margin Assessment in Soft Tissue Sarcoma.

Lauren Zeitlinger, George M Chavez, Machelle D Wilson, Morgan Darrow, Robert J Canter, R Lor Randall, Steven W Thorpe

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of surgical oncology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
  2. Review
  3. Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Lauren ZeitlingerDepartment of Orthopaedic Surgery, University of Pittsburgh Medical Center Central Pennsylvania, Harrisburg, Pennsylvania, USA.
George M ChavezDepartment of Orthopaedic Surgery, University of California, Davis Medical Center, Sacramento, California, USA.
Machelle D WilsonClinical and Translational Science Center, University of California, Davis Medical Center, Sacramento, California, USA.
Morgan DarrowDepartment of Pathology, University of California, Davis Medical Center, Sacramento, California, USA.
Robert J CanterDivision of Surgical Oncology, Department of Surgery, University of California, Davis Medical Center, Sacramento, California, USA.ORCID http://orcid.org/0000-0002-3331-5418
R Lor RandallDepartment of Orthopaedic Surgery, University of California, Davis Medical Center, Sacramento, California, USA.ORCID http://orcid.org/0000-0002-3660-774X
Steven W ThorpeDepartment of Orthopedics, University of Colorado Anschutz Medical Campus, Aurora, Colorado, USA.ORCID http://orcid.org/0000-0003-3127-4912

Funding

UC Davis Clinical and Translational Science CenterUL1TR001860 · NCATS · UNIVERSITY OF CALIFORNIA AT DAVIS · PI KENYON, NICHOLAS J., LYLES, COURTNEY REES · 2016 to 2025
$47.3M
NCATS NIH HHS UL1 TR001860The project described was supported by the National Center for Advancing Translational Sciences, National Institutes of Health, through grant number UL1 TR001860.
6 · The paper itself

Abstract

BACKGROUND/

objectivesIntraoperative peripheral margin sampling in soft tissue sarcoma (STS) is a routine practice among musculoskeletal oncologists. Practice patterns are variable, and evidence to support it is lacking. Rates of peripheral margin sampling at our institution were analyzed in addition to its clinical utility and cost-effectiveness.

methodsPeripheral margin sampling patterns at a tertiary sarcoma center were retrospectively evaluated. Concordance between peripheral margins and final pathology was assessed using McNemar's test and κ Coefficient. Clinical outcomes were compared, and a cost-utility analysis was performed.

resultsA total of 179 patients were included. 66% had peripheral margins sampled of which 23% had frozen margins analyzed. Ten patients had positive margins (5.5% of all patients; 8.4% in those with margins sampled) and R1 margins on the final tumor specimen were identified in 15 patients (8.4%). There were no R2 resections. Three patients underwent repeat surgical resection (20%). Three patients with R1 resections had negative peripheral margins sampled, suggesting falsely reassuring peripheral margins. Peripheral margin sampling averaged $5000/patient.

conclusionsRoutine peripheral margin sampling in STS resection is of questionable utility with added cost. Prospective studies are warranted to determine the optimal approach to surgical margin assessment.

Indexed as

Frozen SectionsMargins of ExcisionSarcomaSoft Tissue NeoplasmsAdultAgedAged, 80 and overCost-Benefit AnalysisFemaleHumansIntraoperative CareMaleMiddle AgedRetrospective StudiesYoung Adultintraoperative margin assessmentperipheral marginssarcomasoft tissue sarcomasurgical margins

Identifiers

PMID39523913
PMCPMC12065663

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.