Evidence map›Paper›PMID 39523667›Full record

ReviewBJPsych open2024

Post-traumatic stress disorder and symptoms in paediatric cancer survivors and their family nucleus: systematic review, meta-analysis and meta-regression.

Chen Ee Low, Sheryl Yen Pin Tan, Andre Loh, Jingrong Yu, Joel Zuo Er Ong, Caitlin Yuen Ling Loh, Chun En Yau, Ainsley Ryan Yan Bin Lee, Cyrus Su Hui Ho

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in BJPsych open, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed, 3 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 3 syntheses or guidelines pooled it.

  1. Pregnancy after cancer: FIGO Best practice advice.International journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics · 2025
    Guideline
  2. Pooled it
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Chen Ee LowYong Loo Lin School of Medicine, National University of Singapore, Singapore.ORCID https://orcid.org/0000-0002-8652-0984
Sheryl Yen Pin TanYong Loo Lin School of Medicine, National University of Singapore, Singapore.
Andre LohYong Loo Lin School of Medicine, National University of Singapore, Singapore.
Jingrong YuYong Loo Lin School of Medicine, National University of Singapore, Singapore.
Joel Zuo Er OngYong Loo Lin School of Medicine, National University of Singapore, Singapore.
Caitlin Yuen Ling LohYong Loo Lin School of Medicine, National University of Singapore, Singapore.
Chun En YauYong Loo Lin School of Medicine, National University of Singapore, Singapore.
Ainsley Ryan Yan Bin LeeYong Loo Lin School of Medicine, National University of Singapore, Singapore.
Cyrus Su Hui HoDepartment of Psychological Medicine, Yong Loo Lin School of Medicine, National University of Singapore, Singapore; and Department of Psychological Medicine, National University Hospital, Singapore.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundVarious studies have highlighted the increased incidence and symptoms of depression and anxiety in paediatric cancer survivors (PCS). Yet no meta-analysis has focused on post-traumatic stress disorder (PTSD) or post-traumatic stress symptoms (PTSS) in PCS and their family nucleus.

aimsTo evaluate the overall risk of PTSD and severity of PTSS in PCS and their family nucleus. Secondary objectives include identifying potential risk factors of PTSD and high PTSS.

methodWe systematically searched PubMed, Embase and PsycINFO for studies comparing the risk of PTSD and PTSS severity among PCS, their family nucleus and non-cancer controls. PRISMA reporting guidelines were followed. Random effects meta-analyses and meta-regressions were conducted.

resultsFrom 1089 records, we included 21 studies. PCS have an increased risk of PTSD (risk ratio 2.36, 95% CI 1.37-4.06) and decreased PTSS severity (standardised mean difference -0.29, 95% CI -0.50 to -0.08). Subgroup analyses of other categorical study-level characteristics revealed that female PCS who were older at diagnosis and data collection had a significantly higher risk of PTSD. Meta-regression were insignificant. Family nucleus did not show a significantly increased risk of PTSD (risk ratio 1.13, 95% CI 0.59-5.00) and PTSS severity (standardised mean difference 0.53, 95% CI -0.00 to 1.06). Systematically reviewing studies on the family nucleus found that the majority reported a significantly increased risk of psychological trauma compared with the comparator. Lower education, income and social status were also risk factors.

conclusionsTimely identification and interventions are imperative for policy makers and healthcare providers to prevent trauma from worsening in this population group.

Indexed as

carerschild and adolescent psychiatrymeta-analysissystematic reviewTrauma and stressor-related disorders

Identifiers

PMID39523667
PMCPMC11698174

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.