Evidence map›Paper›PMID 39523633›Full record

ArticleJournal of oral pathology & medicine : official publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology2025

Stroma-and Tumor-Associated Predictive Features in Salivary Gland Adenoid Cystic Carcinoma of the Head and Neck.

Aleksi Rytkönen, Hanna K Laine, Antti Mäkitie, Caj Haglund, Jaana Hagström, Alhadi Almangush, Ilmo Leivo

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Article in Journal of oral pathology & medicine : official publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Aleksi RytkönenDepartment of Pathology, Oulu University Hospital, Oulu, Finland.
Hanna K LaineDepartment of Oral Pathology and Radiology, University of Turku and Turku University Hospital, Turku, Finland.ORCID https://orcid.org/0000-0001-8156-6820
Antti MäkitieDepartment of Otorhinolaryngology-Head and Neck Surgery, University of Helsinki and Helsinki University Hospital, Helsinki, Finland.
Caj HaglundResearch Programs Unit, Translational Cancer Medicine Program, University of Helsinki, Helsinki, Finland.
Jaana HagströmDepartment of Oral Pathology and Radiology, University of Turku and Turku University Hospital, Turku, Finland.ORCID https://orcid.org/0000-0001-6079-7881
Alhadi AlmangushResearch Program in Systems Oncology, Faculty of Medicine, University of Helsinki, Helsinki, Finland.
Ilmo LeivoInstitute of Biomedicine, Pathology, University of Turku and Turku University Central Hospital, Turku, Finland.

Funding

Finnish Cancer SocietyFinska LäkaresällskapetMaritza and Reino Salonen FoundationTurku University Hospital Fund
6 · The paper itself

Abstract

backgroundThere is lack of knowledge on the utility of prognostic histopathologic characteristics in adenoid cystic carcinoma (ACC) of the head and neck. We evaluated the prognostic value of tumor and stroma-related histopathologic features in ACC. MATERIALS AND

methodsA total of 65 cases of ACC from minor and major salivary glands were included in this study. We evaluated tumor budding, tumor-infiltrating lymphocytes (TILs), and tumor-stroma ratio (TSR) in hematoxylin and eosin (HE) stained sections.

resultsStroma-rich ACCs recurred more frequently (p = 0.029) during follow-up and associated with distant metastasis (p = 0.038). In multivariable analysis, stroma-rich tumors associated with poorer disease-specific survival with a hazard ratio of 3.76 (95% CI 1.10-12.83, p = 0.034). ACCs commonly showed a low infiltration of TILs as 89% of the tumors was characterized by an immune desert pattern. Low infiltration of TILs associated significantly with increased tumor budding (p = 0.039).

conclusionAdverse features of TSR and tumor budding are widely expressed in ACC, and stroma-rich tumors are associated with poor prognosis. Low number of TILs in ACC tissue indicates a weak immune response by the host and illustrates the nature of ACC as a relentless malignancy.

Indexed as

Carcinoma, Adenoid CysticHead and Neck NeoplasmsSalivary Gland NeoplasmsAdultAgedAged, 80 and overFemaleHumansLymphocytes, Tumor-InfiltratingMaleMiddle AgedNeoplasm Recurrence, LocalPrognosisRetrospective StudiesStromal Cellsadenoid cystic carcinomasurvivaltumor buddingtumor‐infiltrating lymphocytestumor‐stroma ratio

Identifiers

PMID39523633
PMCPMC11730399

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.