Evidence map›Paper›PMID 39523540›Full record

ArticleACS chemical neuroscience2024

Aromatic Amino Acid Hydroxylases as Off-Targets of Histone Deacetylase Inhibitors.

Anne Baumann, Niklas Papenkordt, Dina Robaa, Peter D Szigetvari, Anja Vogelmann, Franz Bracher, Wolfgang Sippl, Manfred Jung, Jan Haavik

Abstract read
In one paragraph

Article in ACS chemical neuroscience, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Iron dysregulation in the central nervous system: implications for autism spectrum disorder.Biometals : an international journal on the role of metal ions in biology, biochemistry, and medicine · 2026
    Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Anne BaumannDepartment of Biomedicine, University of Bergen, 5007 Bergen, Norway.
Niklas PapenkordtInstitute of Pharmaceutical Sciences, University of Freiburg, 79104 Freiburg, Germany.ORCID 0000-0003-3420-0695
Dina RobaaInstitute of Pharmacy, Martin-Luther University of Halle - Wittenberg, 06120 Halle/Saale, Germany.
Peter D SzigetvariDepartment of Biomedicine, University of Bergen, 5007 Bergen, Norway.ORCID 0000-0002-1821-2779
Anja VogelmannInstitute of Pharmaceutical Sciences, University of Freiburg, 79104 Freiburg, Germany.
Franz BracherDepartment of Pharmacy - Center for Drug Research, Ludwig-Maximilians University Munich, 81377 Munich, Germany.ORCID 0000-0003-0009-8629
Wolfgang SipplInstitute of Pharmacy, Martin-Luther University of Halle - Wittenberg, 06120 Halle/Saale, Germany.ORCID 0000-0002-5985-9261
Manfred JungInstitute of Pharmaceutical Sciences, University of Freiburg, 79104 Freiburg, Germany.ORCID 0000-0002-6361-7716
Jan HaavikDepartment of Biomedicine, University of Bergen, 5007 Bergen, Norway.ORCID 0000-0001-7865-2808

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The aromatic amino acid hydroxylases (AAAHs) phenylalanine hydroxylase, tyrosine hydroxylase, and tryptophan hydroxylases 1 and 2 are structurally related enzymes that contain an active site iron atom and depend on tetrahydrobiopterin (BH

Indexed as

Histone Deacetylase InhibitorsTryptophan HydroxylaseHumansHydroxamic AcidsIndolesPanobinostatPhenylalanine HydroxylaseTyrosine 3-MonooxygenaseHistone Deacetylase InhibitorsHydroxamic AcidsIndolesPanobinostatPhenylalanine HydroxylaseTPH1 protein, humanTryptophan HydroxylaseTyrosine 3-Monooxygenaseepigeneticshistone deacetylaseiron chelatorsphenylalanine hydroxylasetryptophan hydroxylasetyrosine hydroxylase

Identifiers

PMID39523540
PMCPMC11587510

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.