Evidence map›Paper›PMID 39523506›Full record

ReviewBMB reports2024

DNA regulatory element cooperation and competition in transcription.

Haram Lee, Meyer Joseph Friedman, Sang Bum Kim, Soohwan Oh

Abstract readReview
In one paragraph

Review in BMB reports, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Enhancer regulation in cancer: from epigenetics to mArchives of pharmacal research · 2025
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Haram LeeDepartment of Pharmacy, College of Pharmacy, Korea University, Sejong 30019, Korea.
Meyer Joseph FriedmanDepartment and School of Medicine, University of California, San Diego, CA 92093, USA.
Sang Bum KimDepartment of Pharmacy, College of Pharmacy, Sahmyook University, Seoul 01795, Korea.
Soohwan OhDepartment of Pharmacy, College of Pharmacy, Korea University, Sejong 30019, Korea.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Regulation of eukaryotic transcription is a complex process that enables precise temporal and spatial control of gene expression. Promoters, which are cis-regulatory elements (CREs) located proximal to the transcription start site (TSS), selectively integrate regulatory cues from distal CREs, or enhancers, and their associated transcriptional machinery. In this review, we discuss current knowledge regarding CRE cooperation and competition impacting gene expression, including features of enhancer-promoter, enhancer-enhancer, and promoter-promoter interplay. We also provide an overview of recent insights into the underlying molecular mechanisms that facilitate physical and functional interaction of regulatory elements, such as the involvement of enhancer RNAs and biomolecular condensates. [BMB Reports 2024; 57(12): 509-520].

Indexed as

Enhancer Elements, GeneticGene Expression RegulationPromoter Regions, GeneticTranscription, GeneticAnimalsDNAHumansRegulatory Sequences, Nucleic AcidDNA

Identifiers

PMID39523506
PMCPMC11693600

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.