Evidence map›Paper›PMID 39523475›Full record

ArticleThe Journal of antimicrobial chemotherapy2025

Clinical outcomes following acute sore throat assessment at community pharmacy versus general practice: a retrospective, longitudinal, data linkage study.

Efi Mantzourani, Haroon Ahmed, Jackie Bethel, Samantha Turner, Ashley Akbari, Andrew Evans, Matthew Prettyjohns, Gareth John, Ronny Gunnarsson, Rebecca Cannings-John

Abstract readComparative Study
In one paragraph

Article in The Journal of antimicrobial chemotherapy, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed.

  1. Article
  2. Article
  3. Review
  4. Article
  5. Article
  6. Article
  7. Article
  8. Yonder: Antidepressant follow-up, NHS app use, sore throats in community pharmacy, and dementia and anticholinergics.The British journal of general practice : the journal of the Royal College of General Practitioners · 2025
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Efi MantzouraniCardiff School of Pharmacy and Pharmaceutical Sciences, Cardiff University, Cardiff, Wales, UK.ORCID 0000-0002-6313-1409
Haroon AhmedDivision of Population Medicine, Cardiff University, Cardiff, Wales, UK.ORCID 0000-0002-0634-8548
Jackie BethelDivision of Population Medicine, Cardiff University, Cardiff, Wales, UK.
Samantha TurnerPopulation Data Science, Swansea University Medical School, Swansea University, Swansea, Wales, UK.
Ashley AkbariPopulation Data Science, Swansea University Medical School, Swansea University, Swansea, Wales, UK.ORCID 0000-0003-0814-0801
Andrew EvansPrimary Care Services, Welsh Government, Cardiff, Wales, UK.ORCID 0000-0001-9486-283X
Matthew PrettyjohnsHealth Technology Wales, Velindre NHS Trust, Cardiff, Wales, UK.
Gareth JohnDigital Health and Care Wales, NHS Wales, Cardiff, Wales, UK.
Ronny GunnarssonSchool of Public Health and Community Medicine, University of Gothenburg, Gothenburg, Sweden.
Rebecca Cannings-JohnCentre for Trials Research, Cardiff University, Cardiff, Wales, UK.

Funding

Digital Health
6 · The paper itself

Abstract

backgroundTo date, no research has compared longer-term outcomes (antibiotic provision; re-consultations; hospital admissions for quinsy; cost-effectiveness) following presentation with acute sore throat at general practice (GP) versus newer, pharmacy-led services.

methodsA retrospective, longitudinal cohort study of sore throat consultations between 1 November 2018 and 28 February 2020 either with the Wales pharmacy-led sore throat test and treat (STTT) service or with a healthcare professional at GP. Individual-level pharmacy consultation data from the national Choose Pharmacy IT application were securely uploaded to the Secure Anonymised Information Linkage Databank and linked to routinely collected, anonymized, population-scale, individual-level, anonymized health and administrative data.

resultsOf 72 736 index consultations, 6495 (8.9%) were with STTT and 66 241 (91.1%) with GP. Antibiotic provision at the index consultation was 1382 (21%) with STTT and 25 506 (39%) with GP [adjusted odds ratio (AOR), 0.30; 95% CI, 0.27 to 0.32]. Antibiotic provision within 28 days of index occurred in 1820 (28%) STTT and 26 369 (40%) GP consultations (AOR, 0.44; 95% CI, 0.41 to 0.47). GP re-consultation rate within 28 days of index date was 21% (n = 1389) with STTT compared with 7.4% (n = 4916) with GP (AOR, 3.8; 95% CI, 3.5 to 4.1). Coding limitations may lead to overestimates of GP re-consultations rates in the STTT group. Hospital admissions for quinsy were rare in both STTT (n = 20, 0.31%) and GP (n = 274, 0.41%) (AOR, 0.68; 95% CI, 0.43 to 1.1). STTT was less costly than consultation with GP.

conclusionsThe pharmacy-led STTT service is safe, cost-effective, and contributes to antimicrobial stewardship.

Indexed as

Anti-Bacterial AgentsGeneral PracticePharyngitisAdolescentAdultAgedCost-Benefit AnalysisFemaleHospitalizationHumansInformation Storage and RetrievalLongitudinal StudiesMaleMiddle AgedPharmaciesReferral and ConsultationAnti-Bacterial Agents

Identifiers

PMID39523475
PMCPMC11695917

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.